Microdevices in Mass Spectrometry

Foret, František; Kusý, Petr

doi:10.1255/ejms.834

Cited by 11 publications

(7 citation statements)

References 47 publications

(44 reference statements)

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“…In recent years there has been growing interest in the miniaturization of analytical devices to the advantages that can be achieved over conventional systems 1, 2. These include higher sensitivity, faster analysis, reduced sample and solvent consumption, and lower manufacturing cost.…”

mentioning

confidence: 99%

Gas chromatography/mass spectrometry of polychlorinated biphenyls using atmospheric pressure chemical ionization and atmospheric pressure photoionization microchips

Luosujärvi

Karikko

Haapala

et al. 2008

Rapid Comm Mass Spectrometry

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Gas chromatography (GC) and ion trap mass spectrometry (MS) were combined with microchip atmospheric pressure chemical ionization (microAPCI) and microchip atmospheric pressure photoionization (microAPPI) sources. Selected polychlorinated biphenyls (PCBs, IUPAC Nos. 28, 52, 101, 118, 138, 153 and 180) were analyzed by GC/microAPCI-MS and GC/microAPPI-MS to demonstrate the applicability of the miniaturized ion sources in negative ion mode analysis. The microAPCI and microAPPI methods were evaluated in respect of detection limit, linearity and repeatability. The detection limits for the PCB congeners were somewhat lower with microAPCI than with microAPPI, whereas microAPPI showed slightly wider linear range and better repeatability. With both methods, the best results were obtained for highly chlorinated or non-ortho-chlorinated PCBs, which possess the highest electron affinities. Finally, the suitability of the GC/microAPPI-MS method for the analysis of PCBs in environmental samples was demonstrated by analyzing soil extracts, and by comparing the results with those obtained by gas chromatography with electron capture detection (GC/ECD).

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mentioning

confidence: 99%

Gas chromatography/mass spectrometry of polychlorinated biphenyls using atmospheric pressure chemical ionization and atmospheric pressure photoionization microchips

Luosujärvi

Karikko

Haapala

et al. 2008

Rapid Comm Mass Spectrometry

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“…When coupled with MS, the method is exceptionally capable of profiling complicated glycan mixtures. Miniaturization is also revolutionizing analytical biochemistry by offering a number of advantages such as reduced analyte quantity, lower solvent consumption, and better reproducibility 71 . Devices employing microfluidic technologies are now commercially available.…”

Section: Characterization Of Human Milk Oligosaccharidesmentioning

confidence: 99%

“…Miniaturization is also revolutionizing analytical biochemistry by offering a number of advantages such as reduced analyte quantity, lower solvent consumption, and better reproducibility. 71 Devices employing microfluidic technologies are now commercially available. Laser ablation is used to create laminated polyimide HPLC chip devices.…”

Section: Characterization Of Human Milk Oligosaccharidesmentioning

confidence: 99%

Mass spectrometric methods for analysis of oligosaccharides in human milk

Niñonuevo¹,

Lebrilla

2009

Nutrition Reviews

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Establishing the analytical platforms for characterizing human milk oligosaccharides is important to fully assess their specific functionalities. The characterization of these biomolecules, however, is still considered challenging, owing to their overall complexity and diversity. Addressed here are the technical difficulties with an emphasis on the application of mass spectrometry to rapidly profile and quantify human milk oligosaccharides. Fundamental concepts and improvements in instrumentation and an overview of the biological functions and structures of these compounds are also discussed. Results reveal that small-chain oligosaccharides, evident in abundance in the early stage of lactation, are selectively consumed by specific stains of Bifidobacterium longum biovar, infantis.

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“…M iniaturization of analytical devices has gained a lot of attention in recent years, and a multitude of papers concerning the topic has been published [1][2][3]. In mass spectrometry, the majority of the effort has been put to miniaturization of ion sources, especially electrospray ionization (ESI) [4].…”

mentioning

confidence: 99%

Analysis of selective androgen receptor modulators by gas chromatography-microchip atmospheric pressure photoionization-mass spectrometry

Luosujärvi

Haapala

Thevis

et al. 2010

J. Am. Soc. Mass Spectrom.

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A gas chromatography-microchip atmospheric pressure photoionization-mass spectrometric (GC-APPI-MS) method was developed and used for the analysis of three 2-quinolinone-derived selective androgen receptor modulators (SARMs). SARMs were analyzed from spiked urine samples, which were hydrolyzed and derivatized with N-methyl-N-(trimethylsilyl)trifluoroacetamide before analysis. Trimethylsilyl derivatives of SARMs formed both radical cations (M ϩ• ) and protonated molecules ([M ϩ H] ϩ ) in photoionization. Better signal-to-noise ratios (S/N) were obtained in MS/MS analysis using the M ϩ• ions as precursor ions than using the [M ϩ H] ϩ ions, and therefore the M ϩ• ions were selected for the precursor ions in selected reaction monitoring (SRM) analysis. Limits of detection (LODs) with the method ranged from 0.01 to 1 ng/mL, which correspond to instrumental LODs of 0.2-20 pg. Limits of quantitation ranged from 0.03 to 3 ng/mL. The mass spectrometric response to the analytes was linear (R Ն 0.995) from the LOQ concentration level up to 100 ng/mL concentration, and intra-day repeatabilities were 5%-9%. In addition to the GC-APPI-MS study, the proof-of-principle of gas chromatography-microchip atmospheric pressure chemical ionization-Orbitrap MS (GC-APCI-Orbitrap MS) was demonstrated. (J Am Soc Mass Spectrom 2010, 21, 310 -316)

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Microdevices in Mass Spectrometry

Abstract: Miniaturization of laboratory instrumentation is becoming critical in achieving the speed and throughput required by the current revolutionary progress in biology. This mini review critically summarizes the present status of microfluidic devices designed for use in mass spectrometry.

Cited by 11 publications

References 47 publications

Gas chromatography/mass spectrometry of polychlorinated biphenyls using atmospheric pressure chemical ionization and atmospheric pressure photoionization microchips

Gas chromatography/mass spectrometry of polychlorinated biphenyls using atmospheric pressure chemical ionization and atmospheric pressure photoionization microchips

Mass spectrometric methods for analysis of oligosaccharides in human milk

Analysis of selective androgen receptor modulators by gas chromatography-microchip atmospheric pressure photoionization-mass spectrometry

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