Microemulsion: A Potential Novel Drug Delivery System

Mandavi, Naresh; Ansari, Nazneen; Bharti, Ravi; Kader, N Syed Abdul; Sahu, Gyanesh Kumar; Sharma, Harish

doi:10.5958/0975-4377.2018.00039.3

Cited by 6 publications

(1 citation statement)

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“…They can solubilize both hydrophilic and lipophilic drugs, as well as drugs that are relatively insoluble in both hydrophilic and hydrophobic solvents. The effectiveness of a drug can be enhanced by using microemulsion delivery systems, which lowers the overall dosage and minimizes side effects [156].…”

Section: Microemulsionmentioning

confidence: 99%

Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review

Mirza,

Mahmood,

Hilles

et al. 2023

Pharmaceuticals

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Quercetin is the major polyphenolic flavonoid that belongs to the class called flavanols. It is found in many foods, such as green tea, cranberry, apple, onions, asparagus, radish leaves, buckwheat, blueberry, broccoli, and coriander. It occurs in many different forms, but the most abundant quercetin derivatives are glycosides and ethers, namely, Quercetin 3-O-glycoside, Quercetin 3-sulfate, Quercetin 3-glucuronide, and Quercetin 3′-metylether. Quercetin has antioxidant, anti-inflammatory, cardioprotective, antiviral, and antibacterial effects. It is found to be beneficial against cardiovascular diseases, cancer, diabetes, neuro-degenerative diseases, allergy asthma, peptic ulcers, osteoporosis, arthritis, and eye disorders. In pre-clinical and clinical investigations, its impacts on various signaling pathways and molecular targets have demonstrated favorable benefits for the activities mentioned above, and some global clinical trials have been conducted to validate its therapeutic profile. It is also utilized as a nutraceutical due to its pharmacological properties. Although quercetin has several pharmacological benefits, its clinical use is restricted due to its poor water solubility, substantial first-pass metabolism, and consequent low bioavailability. To circumvent this limited bioavailability, a quercetin-based nanoformulation has been considered in recent times as it manifests increased quercetin uptake by the epithelial system and enhances the delivery of quercetin to the target site. This review mainly focuses on pharmacological action, clinical trials, patents, marketed products, and approaches to improving the bioavailability of quercetin with the use of a nanoformulation.

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Section: Microemulsionmentioning

confidence: 99%

Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review

Mirza,

Mahmood,

Hilles

et al. 2023

Pharmaceuticals

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Formulation and Evaluation of Patchouli Oil Microemulsion and Microemulgel for Inhibit the Bacterial Growth

Febriyenti

Suharti

Putri

2022

RJPT

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Patchouli oil from patchouli leaves (Pogostemon cablin, Benth) is known as the antimicrobial effect. Patchouli oil has been formulated into a gel dosage form. But the appearance of the gel could be improved to microemulsion and microemulgel. The aims of this study are to formulate the patchouli oil to microemulsion and microemulgel form and to determine the effect of the different dosage form to the ability of the patchouli oil to inhibit bacterial growth. Patchouli oil has been formulated to microemulsion (M) and microemulgel (MG) with three different concentrations i.e., 2%, 4%, and 6%. Evaluation of the resulting formulas included examining its general appearance, homogeneity, pH, stability test, spreadability test, and inhibition of bacterial growth. The results showed that patchouli oil microemulsion thinner than patchouli oil microemulgel. Microemulsion and microemulgel dosage forms were not affecting the ability of patchouli oil to inhibit of Citrobacter diversus and Staphylococcus .aureus bacterial growth.

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Role of Surfactant and Co-surfactant in Microemulsion: A Review

Ande

Sonone

Bakal

et al. 2022

RJPT

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Microemulsions are one in all the most effective candidates as novel drug delivery system due to their long time period stability, improved drug solubilization with simple preparation and administration. Surfactants and cosurfactants play crucial role to get stable, mild and clinically acceptable microemulsions in their optimized concentration, The main aim of the study to produce an efficient screening approach for the surfactant and cosurfactant selection for the excipients of microemulsion formulation development and to check the consequences of surfactant hydrophilic–lipophilic balance (HLB) as well solubilization stability process in microemulsion. The composition and extent of surfactants and cosurfactants were key variables for physicochemical properties of drug-loaded Microemulsions. The important aspects must be considered for a successful microemulsion process is that the stability of the liquid membrane. This study is an attempt to grasp the mechanism of the effect of the surfactant and chain length of co-surfactants within the microemulsion base formulation stability.

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Microemulsion: A Potential Novel Drug Delivery System

Cited by 6 publications

References 0 publications

Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review

Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review

Formulation and Evaluation of Patchouli Oil Microemulsion and Microemulgel for Inhibit the Bacterial Growth

Role of Surfactant and Co-surfactant in Microemulsion: A Review

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