Microemulsion as a tool for the transdermal delivery of ondansetron for the treatment of chemotherapy induced nausea and vomiting

Abood, Raid M. Al; Talegaonkar, Sushama; Tariq, Mohammad; Ahmad, Feroz

doi:10.1016/j.colsurfb.2012.06.015

Cited by 50 publications

(26 citation statements)

References 39 publications

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“…This result is in accordance with literature reported by [13] that also indicate the smaller area of microemulsion region when used PEG 400 as a co-surfactant, IPM as an oil phase and Brij 30/Brij 35 (HLB ~11.1) as a surfactant. Meanwhile, the result of OA based system is in good agreement with the previous study conducted by [14] that shows stable microemulsion system consisting of oleic acid (oil phase), Tween 20 (surfactant), PEG 400 (co-surfactant), water (aqueous phase). These results might be due to the fact that the lower the molecular volume of oils, the greater the surfactant efficiency [15].…”

Section: Effect Of Oa and Ipm On The System Of Brij 97/peg 400/watersupporting

confidence: 79%

Study on the Effect of Oil Phase and Co-Surfactant on Microemulsion Systems

Sisak

Daik²,

Ramli³

2017

MJAS

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The purpose of the present study was to investigate the effect of different oil and chain lengths of co-surfactant on microemulsion region. Oleic acid and isopropyl myristate were used as the oil phase, transcutol, polyethylene glycol 400 (PEG 400) and propylene glycol as co-surfactant and Brij 97 as a surfactant. From the ternary phase diagrams, isopropyl myristate based system is more feasible oil phase to formulate microemulsion compared to oleic acid based system. Moreover, transcutol (medium chain length) is the most suitable co-surfactant to blend with a single-chain surfactant, Brij 97 in order to have a high stability and a large area of microemulsion region.Keywords: microemulsion, oleic acid, isopropyl myristate, transcutol, propylene glycol Abstrak Kajian ini bertujuan untuk mengkaji kesan minyak yang berbeza dan panjang rantai ko-surfaktan terhadap rantau mikroemulsi. Asid oleik dan isopropil miristat telah digunakan sebagai fasa minyak, transcutol, polietilena glikol 400 (PEG 400) dan propilena glikol sebagai ko-surfaktan dan Brij 97 sebagai surfaktan. Berdasarkan rajah fasa tenari, sistem berasaskan isopropil miristat adalah fasa minyak yang lebih sesuai untuk membentuk mikroemulsi berbanding sistem berasaskan asid oleik. Selain itu, transcutol yang berantai sederhana panjang adalah ko-surfaktan yang sesuai untuk diformulasikan bersama surfaktan rantai tunggal, Brij 97 yang memberikan rantau kawasan mikroemulsi yang besar dengan kestabilan yang tinggi.Kata kunci: mikroemulsi, asid oleik, isopropil miristat, transcutol, propilena glikol Introduction Microemulsions are versatile systems and can be used in various applications such as for cutting oils, corrosion inhibitors, biotechnology, fuels, coating and textile finishing, food industries, lubricants, and also in pharmaceuticals [1]. Microemulsions have generated extensive interest over the years as potential drug delivery systems, especially for the delivery of the hydrophilic and lipophilic drug [2]. It is because of its several characteristics such as improved drug solubilization, longer shelf life, ease of preparation and improvement of bioavailability of poorly soluble drugs [3]. It is also can be used to deliver drugs via several routes and making them as a promising dermal delivery of the drug through an efficient route of drug administration [4].

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Section: Effect Of Oa and Ipm On The System Of Brij 97/peg 400/watersupporting

confidence: 79%

Study on the Effect of Oil Phase and Co-Surfactant on Microemulsion Systems

Sisak

Daik²,

Ramli³

2017

MJAS

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“…The prepared skin was wrapped in aluminum foil and stored in a deep freezer at −30°C for further use. (32,33) Prior usage methylene blue dye test was performed to assess the skin integrity (34). Ex vivo skin permeation studies were conducted on Franz diffusion cells (PermeGear, Inc., Hellertown, PA, USA).…”

Section: Ex Vivo Permeation Studiesmentioning

confidence: 99%

Benzyl Benzoate-Loaded Microemulsion for Topical Applications: Enhanced Dermatokinetic Profile and Better Delivery Promises

et al. 2015

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Abstract. Benzyl benzoate (BB) is one of the oldest drugs used for the treatment of scabies and is recommended as the "first-line intervention" for the cost-effective treatment of the disease. Though a promising candidate, its application is reported to be associated with irritation of the skin and eye, resulting in poor patient compliance. Hence, the present study aims to develop BB-loaded topical microemulsion for the safer and effective delivery of BB. Pseudo-ternary phase diagrams with BB as the oily phase itself, along with Tween 80 as surfactant, and mixture of phospholipid and ethanol as the cosurfactant along with aqueous solution as the external phase were constructed and various compositions were formulated. The optimized formulation was characterized for particle-size, zeta-potential, drugcontent, globule-morphology pH, and refractive-index, whereas evaluated for skin permeation, retention, compliance, and dermatokinetics. The nanosized formulation offered threefold higher drug permeation vis-a-vis plain drug solution across LACA mice abdominal skin. The drug retention of the selected formulation was nearly twice of that from the marketed product, assuring depot formulation and sustained release. The skin histopathology revealed the non-irritant nature of the formulation, as no changes in the normal skin histology were observed. The dermatokinetic studies confirmed better permeation and enhanced skin bioavailability of BB to epidermis as well as dermis vis-à-vis the conventional product. The results indicate that the developed lipid-based microemulsion hydrogel can alleviate the concerns associated with BB and can provide a better and safer delivery option in substantial amounts to various skin layers.

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“…Consequently, the toxicity and side effects might increase. 27 Therefore, the oil phase selected should mainly be based on the drug solubility in the oil phase. The solubility of GM in various oils, surfactants, and cosurfactants was analyzed, and the results are shown in Table 1.…”

Section: Results and Discussion Solubility Studymentioning

confidence: 99%

“…The surfactant was selected mainly because of its solubility capacity for oil, and the good solubility capacity for drug was not related to its good affinity for the oil phase. 27 The solubility of GM was higher in Cremophor RH40 than in Cremophor EL, which might be the main reason that the solubility of GM in F-2 was greater than that in F-4 and F-5 (see Table 1). Among the five ME formulations, F-2 had the highest solubilization capacity, and Cremophor RH40 as a surfactant used in F-2 led to improve drug solubility.…”

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confidence: 99%

Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique

Li¹,

Pan²,

Cui³

et al. 2016

IJN

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The objective of this work was to prepare an oil/water glimepiride (GM) microemulsion (ME) for oral administration to improve its solubility and enhance its bioavailability. Based on a solubility study, pseudoternary phase diagrams, and Box–Behnken design, the oil/water GMME formulation was optimized and prepared. GMME was characterized by dynamic laser light scattering, zeta potential, transmission electron microscopy, and viscosity. The in vitro drug release, storage stability, pharmacodynamics, and pharmacokinetics of GMME were investigated. The optimized GMME was composed of Capryol 90 (oil), Cremophor RH40 (surfactant), and Transcutol (cosurfactant), and increased GM solubility up to 544.6±4.91 µg/mL. The GMME was spherical in shape. The particle size and its polydispersity index were 38.9±17.46 nm and 0.266±0.057, respectively. Meanwhile, the GMME was physicochemically stable at 4°C for at least 3 months. The short-term efficacy in diabetic mice provided the proof that blood glucose had a consistent and significant reduction at a dose of 375 µg/kg whether via IP injection or IG administration of GMME. Compared with the glimepiride suspensions or glimepiride-meglumine complex solution, the pharmacokinetics of GMME in Wistar rats via IG administration exhibited higher plasma drug concentration, larger area under the curve, and more enhanced oral bioavailability. There was a good correlation of GMME between the in vitro release values and the in vivo oral absorption. ME could be an effective oral drug delivery system to improve bioavailability of GM.

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Microemulsion as a tool for the transdermal delivery of ondansetron for the treatment of chemotherapy induced nausea and vomiting

Cited by 50 publications

References 39 publications

Study on the Effect of Oil Phase and Co-Surfactant on Microemulsion Systems

Study on the Effect of Oil Phase and Co-Surfactant on Microemulsion Systems

Benzyl Benzoate-Loaded Microemulsion for Topical Applications: Enhanced Dermatokinetic Profile and Better Delivery Promises

Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique

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