Microemulsion Systems: Prospective Approach for Superior Drug Delivery

Kesavan, Karthikeyan; Gautam, Nivedita; Bharti, Shanni K.; Mohan, Parasuraman

doi:10.2174/2210303107666170929111420

Cited by 4 publications

(2 citation statements)

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“…The primary goal of any ophthalmic topical drug delivery system is to improve the precorneal residence time, maintain a therapeutic drug concentration level at the target site, reduce the frequency of administration and overcome the various ocular barriers. Among the different nanosystems described in the literature, microemulsions (MEs), which are transparent colloidal oil-in-water (O/W) or water-in-oil (W/O) nanodispersions, that present sizes between 5 and 200 nm with significant thermodynamic stability and low surface tension [ 26 ], seem to be adequate to be administered topically as ophthalmic delivery systems owing to their ease of preparation and sterilization, and to their supersolvent properties allowing to deliver both hydrophilic and lipophilic drugs. Several studies on this topic are reported in the literature [ 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab

et al. 2021

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Bevacizumab (BVZ), a recombinant humanized monoclonal antibody, has recently been proposed as a topical application in the treatment of anterior segment neovascularization; however, as there are some disadvantages in the administration of common eye-drops, ophthalmic topical drug delivery systems are under study to improve the precorneal residence time, reducing the frequency of administration. In this work, oil-in-water and water-in-oil BVZ-loaded microemulsions are developed, able to increase their viscosity, either by the formation of a liquid-crystalline structure upon aqueous dilution, thanks to the presence of Epikuron® 200 and polysorbate 80, or by body-temperature-induced jellification for the presence of Pluronic® F127 aqueous solution as an external phase. In oil-in-water microemulsion, hydrophobic ion pairs of BVZ were also prepared, and their incorporation was determined by release studies. Microemulsions were characterized for rheological behavior, corneal opacity, in vitro corneal permeation, and adhesion properties. The studied microemulsions were able to incorporate BVZ (from 1.25 to 1.6 mg/mL), which maintained dose-dependent activity on retinal pigment epithelial ARPE-19 cell lines. BVZ loaded in microemulsions permeated the excised cornea easier (0.76–1.56% BVZ diffused, 4–20% BVZ accumulated) than BVZ commercial solution (0.4% BVZ diffused, 5% accumulated) and only a mild irritation effect on the excised cornea was observed. The good adhesion properties as well the increased viscosity after application, under conditions that mimic the corneal environment (from 1 × 103 to more than 100·× 103 mPa·s), might prolong precorneal residence time, proving these systems could be excellent topical BVZ release systems.

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Section: Introductionmentioning

confidence: 99%

Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab

et al. 2021

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“…ÌÝ èñïîëüçóþò ïðè ïåðîðàëüíîì, ïàðåíòåðàëüíîì (èíúåêöèè è êàïåëüíèöû, ìèíóÿ ïèùåâàðèòåëüíûé òðàêò), ìåñòíîì (íàíåñåíèå íà êîaeó) è òðàíñäåðìàëüíîì ñïîñîáàõ ââåäåíèÿ ëåêàðñòâåííûõ ñðåäñòâ. Èõ õàðàêòåðíîé ÷åðòîé ÿâëÿåòñÿ âîçìîaeíîñòü ââîäèòü â èõ ñîñòàâ êàê âîäî-, òàê è aeèðîðàñòâîðèìûå êîìïîíåíòû, îáåñïå÷èâàÿ â äàëüíåéøåì áîëåå âûñîêóþ àáñîðáöèþ àêòèâíûõ êîìïîíåíòîâ íåïîâðåaeäåííûì ó÷àñòêîì êîaeíîãî ïîêðîâà [4]. Ïðèâëåêàòåëüíûìè ýìóëüñèè ÿâëÿþòñÿ òàêaeå ñ òî÷êè çðåíèÿ ïðîñòîòû ïðîèçâîäñòâà è âûñîêîé ðàñòâîðÿþùåé ñïîñîáíîñòè.…”

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Микроэмульсии Как Перспективная Основа Для Создания Современных Трансдермальных Терапевтических Систем

Гильдеева¹,

Юрков²

2018

Хим.-фарм. ж.

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Рассмотрены перспективные направления поиска универсальных носителей активных фармацевтических ингредиентов. Трансдермальный перенос действующих веществ (ДВ) лекарственных средств (ЛС) все больше привлекает внимание создателей лекарственных препаратов. Трансдермальная терапевтическая система (ТТС) – лекарственная форма для наружного применения в форме пластырей или пленок, высвобождающая ЛС в течение определенного времени. В зависимости от способа инкорпорирования ДВ ТТС классифицируют на несколько основных типов: резервуарный, адгезивный, матричный и микрорезервуарный. В обзоре описаны способы разработки ТТС на основе микроэмульсий.

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Microemulsions as Potential Bases for Formulating Modern Transdermal Therapeutics

Гильдеева

Yurkov²

2018

Pharm Chem J

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Microemulsion Systems: Prospective Approach for Superior Drug Delivery

Cited by 4 publications

References 0 publications

Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab

Assessment of In-Situ Gelling Microemulsion Systems upon Temperature and Dilution Condition for Corneal Delivery of Bevacizumab

Микроэмульсии Как Перспективная Основа Для Создания Современных Трансдермальных Терапевтических Систем

Microemulsions as Potential Bases for Formulating Modern Transdermal Therapeutics

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