Microemulsions as Potential Bases for Formulating Modern Transdermal Therapeutics

Гильдеева, Г. Н.; Yurkov, V. I.

doi:10.1007/s11094-018-1858-6

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Due to its greaseless and thixotropic behavior, emulgel demonstrates an enhanced drug release profile, facilitates spreadability on the skin and increases absorption while preventing typical stability problems associated with emulsions, such as phase separation, creaming and coalescence [6]. In addition, novel drug-carrier systems such as liposomes, niosomes, and microemulsions have demonstrated encouraging results in skin, cutaneous and transdermal delivery of various drugs [8][9][10]. On the other hand, transdermal delivery of protein pharmaceuticals has also been extensively studied [11,12].…”

Section: Introductionmentioning

confidence: 99%

Vesicular Emulgel Based System for Transdermal Delivery of Insulin: Factorial Design and in Vivo Evaluation

et al. 2020

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Transdermal delivery of insulin is a great challenge due to its poor permeability through the skin. The aim of the current investigation was to evaluate the prospective of insulin loaded niosome emulgel as a noninvasive delivery system for its transdermal therapy. A 23 full-factorial design was used to optimize the insulin niosome emulgel by assessing the effect of independent variables (concentration of paraffin oil, Tween 80 and sodium carboxymethyl cellulose) on dependent variables (in vitro release, viscosity and in vitro permeation). The physical characteristics of the prepared formulations were carried out by determining viscosity, particle size, entrapment efficiency, drug loading, drug release and kinetics. In vitro permeation studies were carried out using rat skin membrane. Hypoglycemic activity of prepared formulations was assessed in diabetic-induced rats. It was observed that the independent variables influenced the dependent variables. A significant difference (p < 0.05) in viscosity was noticed between the prepared gels, which in turn influenced the insulin release. The order of permeation is: insulin niosome emulgel > insulin niosome gel > insulin emulgel > insulin gel > insulin niosomes > insulin solution. The enhancement in transdermal flux in insulin niosome emulgel was 10-fold higher than the control (insulin solution). In vivo data significantly demonstrated reduction (p < 0.05) of plasma glucose level (at six hours) by insulin niosome emulgel than other formulations tested. The results suggest that the developed insulin niosome emulgel could be an efficient carrier for the transdermal delivery of insulin.

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Section: Introductionmentioning

confidence: 99%

Vesicular Emulgel Based System for Transdermal Delivery of Insulin: Factorial Design and in Vivo Evaluation

et al. 2020

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“…An important prognostic indicator of ALS is weight loss, primarily through muscle and adipose tissues (39). The percutaneous endoscopic gastrostomy is considered the safest nutritional method (40); however, since the main cause behind weight loss is malnutrition, further exploration of diet options is needed (41)(42)(43)(44)(45). While we acknowledge the availability of direct measures such as body mass index (BMI) for assessing the nutritional status of patients with ALS, the inclusion of biochemical parameters in our study serves a specific purpose.…”

Section: Discussionmentioning

confidence: 99%

Biochemical parameters as a tool to assess the nutritional status of patients with amyotrophic lateral sclerosis

Monov,

Molodozhnikova

2024

Front. Neurol.

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BackgroundThe research aimed to analyze blood biochemical parameters in patients with amyotrophic lateral sclerosis and to determine whether they can be used to assess their nutritional status.MethodsThe study included 45 patients diagnosed with amyotrophic lateral sclerosis (ALS): 28 (62.2%) were men and 17 (37.8%) were women. The mean age of the study participants was 50.69 ± 7.24 years. The control group consisted of 30 practically healthy individuals.ResultsCompared with practically healthy individuals, patients with ALS had significantly lower blood parameters, including total lymphocyte count (1.49 ± 0.11 vs. 2.86 ± 0.25, p < 0.05), total protein (60.55 ± 2.38 vs. 77.80 ± 4.41, p < 0.05), albumin (33.70 ± 2.03 vs. 46.49 ± 3.22, p < 0.05), urea (3.09 ± 0.36 vs. 5.37 ± 0.50, p < 0.05), creatinine (51.28 ± 4.42 vs. 70.91 ± 5.13, p < 0.05), and transferrin (1.84 ± 0.12 vs. 2.32 ± 0.10, p < 0.05). These parameters correspond to first-degree malnutrition. There were direct correlations between anthropometric and biochemical parameters in the ALS group. BMI correlated with the blood levels of total protein (r = 0.22, p < 0.05), albumin (r = 0.27, p < 0.05), urea (r = 0.33, p < 0.05), creatinine (r = 0.30, p < 0.05), transferrin (r = 0.18, p < 0.05), and total lymphocyte count (r = 0.20, p < 0.05). PNI correlated with the blood levels of total protein (r = 0.53, p < 0.05), albumin (r = 0.87, p < 0.05), total cholesterol (r = 0.34, p < 0.05), transferrin (r = 0.40, p < 0.05), total lymphocyte count (r = 0.79, p < 0.05), urea (r = 0, 37, p < 0.05), and creatinine (r = 0.32, p < 0.05).ConclusionThe study presents compelling evidence supporting the utilization of biochemical parameters, including total protein, albumin, urea, creatinine, transferrin, and total lymphocyte count, for potentially evaluating the nutritional status of individuals diagnosed with ALS.

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“…Although the mechanisms of L-carnitine’s effect on lipid and carbohydrate metabolism have been sufficiently studied, there is a need for a broader evidence base to introduce this compound into the diet. This study aims to supplement the existing information and provide more detailed research on the effects of taking L-carnitine compared with taking phospholipids on the activity of liver enzymes and carbohydrate metabolism [ 44 , 45 ]. The purpose of the current study is to assess the efficacy of L-carnitine and its effects on the functional state of the liver, as well as on lipid and carbohydrate metabolism in patients with NASH and concomitant obesity.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of L-carnitine in patients with nonalcoholic steatohepatitis and concomitant obesity

et al. 2023

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Background In light of the high prevalence of nonalcoholic fatty liver disease and obesity, treatment options for nonalcoholic steatohepatitis are of particular interest. The purpose of the study is to assess the efficacy of L-carnitine and its effects on the functional state of the liver, as well as on lipid and carbohydrate metabolism in patients with nonalcoholic steatohepatitis and concomitant obesity. Methods People in the control group followed a hypocaloric diet and received 1 tablet of simvastatin 20 mg once a day and 2 capsules of essential phospholipids 600 mg three times a day for 90 days. People in the experimental group followed a hypocaloric diet and received 1 tablet of simvastatin 20 mg once a day and L-carnitine 10 mL orally two times a day for 90 days. Results L-carnitine normalized the blood lipid profile of subjects, as demonstrated by a significant decrease in the blood levels of total cholesterol, triglycerides, low-density lipoproteins, atherogenic index, and insulin resistance. The use of L-carnitine in patients with nonalcoholic steatohepatitis and concomitant obesity contributes to the steady reduction of the main clinical and biochemical symptoms of nonalcoholic steatohepatitis. Conclusions L-carnitine produces positive effects on the blood lipid profile and carbohydrate metabolism.

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Microemulsions as Potential Bases for Formulating Modern Transdermal Therapeutics

Cited by 5 publications

References 22 publications

Vesicular Emulgel Based System for Transdermal Delivery of Insulin: Factorial Design and in Vivo Evaluation

Vesicular Emulgel Based System for Transdermal Delivery of Insulin: Factorial Design and in Vivo Evaluation

Biochemical parameters as a tool to assess the nutritional status of patients with amyotrophic lateral sclerosis

The efficacy of L-carnitine in patients with nonalcoholic steatohepatitis and concomitant obesity

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