Microemulsions Based Transdermal Drug Delivery Systems

Abstract

Since the discovery of microemulsions by Jack H Schulman, there has been huge progress made in applying microemulsion systems in plethora of research and industrial process. Microemulsions are optically isotropic systems consisting of water, oil and amphiphile. These systems are beneficial due to their thermodynamic stability, optical clarity, ease of preparation, higher diffusion and absorption rates. Moreover, it has been reported that the ingredients of microemulsion can effectively overcome the diffusion barrier and penetrate through the stratum corneum of the skin. Hence it becomes promising for both transdermal and dermal drug delivery. However, low viscosity of microemulsion restrains its applicability in pharmaceutical industry. To overcome the above drawback, the low viscous microemulsions were added to viscous gel bases to potentiate its applications as topical drug delivery systems so that various drug related toxic effects and erratic drug absorption can be avoided. The present review deals with the microemulsions, various techniques involved in the development of organic nanoparticles. The review emphasized on microemulsion based systems such as hydrogels and organogels. The physicochemical characteristics, mechanical properties, rheological and stability principles involved in microemulsion based viscous gels were also explored.

Enhanced and Sustained Cutaneous Delivery of Vismodegib by Ablative Fractional Laser and Microemulsion Formulation

“…To achieve clinical success of AFL-assisted topical vismodegib delivery, a formulation that allows prolonged release of high vismodegib concentrations is required. Emulsions present several significant advantages as topical delivery systems including low risk of LSR, high drug-loading capacity, and increased skin permeation (Nastiti et al, 2017;Vadlamudi et al, 2014). Oil-in-water emulsions in particular offer the opportunity to deliver slow and continuous release of large quantities of hydrophobic drugs with very poor solubility profiles such as vismodegib.…”

Anti-Aging Effects of a Serum Based on Coconut Oil Combined with Deer Antler Stem Cell Extract on a Mouse Model of Skin Aging

“…In order to overcome these limitations, it is necessary to consider many factors such as the skin on the human body, the duration of use, the mechanism of action and possible side effects [ 22 ]. The potential of microemulsions has been of great interest because of its stability, ease of preparation, low viscosity and high solubility for different types of substances including hydrophilic and lipophilic molecules and at the same time enhance product stability and prevent irritation [ 23 , 24 ].…”

Jojoba oil-based microemulsion for transdermal drug delivery

“…Microemulsions have gained wide interest in pharmaceutical formulations as potential drug delivery systems because of their stability, ease of preparation, low viscosity, and high solubilizing capacity for various drugs including hydrophilic and lipophilic molecules. They also may enhance drug stability, prevent irritation caused by some drugs, and may prolong their release ( 1 2 ). Microemulsions are composed of mixtures of oil, water, surfactant, and cosurfactant.…”