Microemulsions for Drug Solubilization and Delivery

Wang, X.Q.; Zhang, Q.

doi:10.1002/9781118444726.ch10

Cited by 1 publication

(4 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained products can be dried by natural solvent evaporation, oven drying or lyophilization. The microemulsions are easily scaled up into a pharmaceutical product [2].…”

Section: Preparation Methods and Characterization Of Emulsionsmentioning

confidence: 99%

“…One factor to evaluate the stability of emulsions is the delamination rate (v) that is calculated according to Stock equation: (2) where d and d 0 are the density of the dispersed phase and the dispersion medium, respectively; g is the gravity acceleration; r is the radius of the dispersed particles; is the viscosity of the dispersion medium. Some solutions applied to reduce G and v values include the use of surfactants or emulsifiers or the use of solvents/solutes with a suitable solubility in the internal and external phases to limit the change between d and d 0 .…”

Section: Emulsion Formation Conditionsmentioning

confidence: 99%

“…Some common emulsifiers are polysorbate 20, polysorbate 80, sorbitan monooleate, polyethylene glycol, glycerin, polyethylene oxide, lecithin, etc. Non-ionic emulsifiers are acceptable in pharmaceuticals [2].…”

Section: Composition Of Emulsionsmentioning

confidence: 99%

“…Up to now, microemulsions have become popular and are increasing dramatically in many fields of application thanks to their advantages such as thermodynamic stability as well as size control of the products [2]. Hoar and Schulman were the first to introduce the notion of microemulsions [3].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Review: emulsion techniques for producing polymer based drug delivery systems

Nguyen

Hoàng

2023

Vietnam J. Sci. Technol.

View full text Add to dashboard Cite

Emulsification method is one of the popular methods for producing materials used inbiosensing, bioimaging and others, especially, drug delivery polymer systems in microsize andnanosize. The concrete techniques related to this method are emulsification, self-emulsification,in a combination with solvent evaporation process, homogenization, or ultranosication. Thestructure of emulsion formulation consists of two phases: an internal phase and an externalphase. Based on the structure and nature of the phases, emulsions can be classified into differenttypes such as two-phase systems (oil in water emulsion (O/W) or water in oil emulsion (W/O))or three-phase systems (water in oil in water triple emulsion (W/O/W) or oil in water in oil tripleemulsion (O/W/O)). The droplet sizes in micro-emulsion systems are often higher than 1 mwhile those in nano-emulsions or mini-emulsions are in the range of 100-500 nm. Some specialnano-emulsion systems can contain droplets with a size of few nanometers. Factors includingsolvents, oil/water phase ratio, droplet oil size, composition ratio, nature of raw materials,emulsifiers, etc. can affect the morphology, properties, and size of the obtained products. Thispaper reviews emulsion techniques which have been applied for producing polymeric drugdelivery systems. The components, properties, characteristics, encapsulation efficiency as wellas drug release rate, water solubility, toxicity and administration efficacy of drug emulsionformulations will be mentioned. Advantages and limitations of emulsion techniques are alsodiscussed.

show abstract

“…The obtained products can be dried by natural solvent evaporation, oven drying or lyophilization. The microemulsions are easily scaled up into a pharmaceutical product [2].…”

Section: Preparation Methods and Characterization Of Emulsionsmentioning

confidence: 99%

Section: Emulsion Formation Conditionsmentioning

confidence: 99%

Section: Composition Of Emulsionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations