Microemulsions strongly promoted the activity of α-bisabolol against different Leishmania species and its skin permeation

Nery dos Santos, Quesia; Teles, Daiane Caroline S.; de Araujo, Guilherme Rodolfo S.; Lima, Odeanny Vitória A.; Silva, Luiz André S.; de Carvalho, Rita de Cássia V.; Carlos de Sousa, Valéria; Matos, Saulo S.; Costa, Amanda Mendonça B.; Andrade-Neto, Valter V.; Torres-Santos, Eduardo Caio; Antunes de S. Araújo, Adriano; Sarmento, Victor Hugo V.; Aécio de Amorim Carvalho, Fernando; de S. Nunes, Rogéria; Lira, Ana Amélia M.

doi:10.1016/j.exppara.2024.108808

Experimental Parasitology

2024

DOI: 10.1016/j.exppara.2024.108808

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Microemulsions strongly promoted the activity of α-bisabolol against different Leishmania species and its skin permeation

Quesia Nery dos Santos,

Daiane Caroline S. Teles,

Guilherme Rodolfo S. de Araujo

et al.

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2024

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Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene

Ivanova,

Ermenlieva,

Andonova

2024

Cosmetics

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The current research is focused on the discovery and optimization of an effective cosmetic carrier of alpha-bisabolol as a first step in the development of a cosmetic product with cleansing and antimicrobial action for facial skin hygiene. A micellar solution of Poloxamer 407 was selected as a cosmetic base because of the good washing ability, easy application, and high tolerability of this polymeric surfactant. The solubilization capacity of a 5% micellar solution with respect to α-bisabolol was investigated by applying varying solubilization techniques and increasing concentrations of the oily active substance. The test samples were subjected to an accelerated physical stability test, viscosimetry, dynamic light scattering (DLS), electrophoretic light scattering (ELS), foamability test, and antimicrobial screening. Over the course of this research, the advantage of the film-hydration method over direct solubilization was demonstrated by the narrower size distribution and smaller hydrodynamic size of the micellar nano-carriers (ranging from 29.02 to 116.5 nm) and the respective higher physical stability of the dispersions. The optimized composition was found to be suitable for application on large skin areas in terms of viscosity in the temperature range from 20 °C to 40 °C (3.4–2.3 mPa.s). Preservation of the washing capacity of the micellar solution in the presence of solubilized α-bisabolol was established. The active composition demonstrated inhibitory activity against Staphylococcus aureus and Escherichia coli and fungicidal activity against Candida albicans. This study concludes that the optimal concentration of α-bisabolol to be solubilized in a 5% Poloxamer 407 micellar solution by the film-hydration technique is 1%, considering the desirable physical endurance and antimicrobial activity.

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Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene

Ivanova,

Ermenlieva,

Andonova

2024

Cosmetics

View full text Add to dashboard Cite

show abstract

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Microemulsions strongly promoted the activity of α-bisabolol against different Leishmania species and its skin permeation

Cited by 1 publication

References 54 publications

Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene

Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene

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