Under the umbrella of “building stones”, a wide range of research topics are possible. A vast interdisciplinary scientific community provides valuable information that should be considered at several levels. These are the extraction of the stone from the quarry to their application on buildings, and the implementation of conservation measures when necessary. The present special issue contains 44 articles on the research into natural building stones. The editorial intention is to present the main highlights of each paper, which are grouped into the following sections in order to better understand the overall content: Quarrying, Physical–Mechanical Properties, Heritage and Weathering, Restoration and Techniques, Miscellaneous. This volume is dedicated to the memory of Professor Rolf Snethlage. The international community of applied geosciences has lost an important researcher and teacher. Therefore, a brief description of importance of the research carried out by Rolf Snethlage is presented at the end of the Editorial.