Microfluidic formulation of pectin microbeads for encapsulation and controlled release of nanoparticles

Ogończyk, Dominika; Siek, Marta; Garstecki, Piotr

doi:10.1063/1.3569944

Cited by 38 publications

(26 citation statements)

References 47 publications

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“…Silicon [168–170], perfluoropolyether [171], polymethyl methacrylate (PMMA) [172, 173], polyurethane [174], polycarbonate [175] and stainless steel [176] microfluidics devices are also reported. In the commonest approach, two streams containing continuous and disperse phases are infused into two separate inlets, and the disperse phase is confined into isolated droplets or narrow stream at T-junction, in flow-focusing and concentric capillaries.…”

Section: Microfluidic Platforms For Dds Fabricationmentioning

confidence: 99%

“…A range of organic (PLA [151, 161] and PLGA [156, 157]) and inorganic (chitosan [172, 173], poly(N-isopropylacrylamide) pNIPAAM [133, 134, 152, 155], hydrogelator [153], silk protein [135], pectin [175], hydrazide and aldehyde-functionalized carbohydrates [158], dextranhydroxyethyl methacrylate (dex-HEMA) [166] and silica [154]) materials have been investigated for microparticle formation through generation of liquid precursor droplets in microfluidics prior to solidification by solvent extraction or induced polymerization (Figure 4b). Furthermore, porous microparticles are also fabricated with the help of microfluidics to facilitate drug release.…”

Section: Microfluidic Platforms For Dds Fabricationmentioning

confidence: 99%

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Advanced materials and processing for drug delivery: The past and the future

Zhang

Chan

Leong

2013

Advanced Drug Delivery Reviews

879

556

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Design and synthesis of efficient drug delivery systems are of vital importance for medicine and healthcare. Materials innovation and nanotechnology have synergistically fueled the advancement of drug delivery. Innovation in material chemistry allows the generation of biodegradable, biocompatible, environment-responsive, and targeted delivery systems. Nanotechnology enables control over size, shape and multi-functionality of particulate drug delivery systems. In this review, we focus on the materials innovation and processing of drug delivery systems and how these advances have shaped the past and may influence the future of drug delivery.

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Section: Microfluidic Platforms For Dds Fabricationmentioning

confidence: 99%

Section: Microfluidic Platforms For Dds Fabricationmentioning

confidence: 99%

Advanced materials and processing for drug delivery: The past and the future

Zhang

Chan

Leong

2013

Advanced Drug Delivery Reviews

879

556

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“…Recently, some studies have exploited the drop generation capabilities of microfluidic devices. Using a T‐junction device, monodisperse alginate drops are produced in micrometer length scales 9–12. The alginate drops are gelled by transferring into a divalent ion solution.…”

Section: Introductionmentioning

confidence: 99%

A Microfluidic Approach to Encapsulate Living Cells in Uniform Alginate Hydrogel Microparticles

Martínez

Kim

et al. 2012

Macromolecular Bioscience

103

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A microfluidic technique is described to encapsulate living cells in alginate hydrogel microparticles generated from monodisperse double-emulsion templates. A microcapillary device is used to fabricate double emulsion templates composed of an alginate drop surrounded by a mineral oil shell. Hydrogel formation begins when the alginate drop separates from the mineral oil shell and comes into contact with Ca(2+) ions in the continuous phase. Alginate hydrogel microparticles with diameters ranging from 60 to 230 µm are obtained. 65% of the cells encapsulated in the alginate microparticles were viable after one week. The technique provides a useful means to encapsulate the living cells in monodisperse hydrogel microparticles.

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Section: Internal Gelationmentioning

confidence: 99%

“…For SPG membrane, blockage is more likely due to tortuous and interconnected pore structure. Another disadvantage of internal gelation is that Ca 2+ could be non-uniformly distributed in the dispersed phase, due to grains of nondissolved CaCO 3 in the beads (Ogończyk et al, 2011).Gelation of alginate with Ca 2+ is a reversible process and the Ca-alginate beads can be solubilised in an aqueous solution containing monovalent ions due to exchange of Ca 2+ with non-cross-linkable monovalent ions. Irreversible alginate gel can be synthesised using alginate with phenol moieties, which can be crosslinked via oxidative C-C and C-O coupling with hydrogen peroxide (Sakai et al, 2007).…”

mentioning

confidence: 99%

Structured microparticles with tailored properties produced by membrane emulsification

Vladisavljević

2015

Advances in Colloid and Interface Science

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This paper provides an overview of membrane emulsification routes for fabrication of structured microparticles with tailored properties for specific applications. Direct (bottom-up) and premix (top-down) membrane emulsification processes are discussed including operational, formulation and membrane factors that control the droplet size and droplet generation regimes. A special emphasis was put on different methods of controlled shear generation on membrane surface, such as cross flow on the membrane surface, swirl flow, forward and backward flow pulsations in the continuous phase and membrane oscillations and rotations. Droplets produced by membrane emulsification can be used for synthesis of particles with versatile morphology (solid and hollow, matrix and core/shell, spherical and non-spherical, porous and coherent, composite and homogeneous), which can be surface functionalised and coated or loaded with macromolecules, nanoparticles, quantum dots, drugs, phase change materials and high molecular weight gases to achieve controlled/targeted drug release and impart special optical, chemical, electrical, acoustic, thermal and magnetic properties. The template emulsions including metal-in-oil, solid-in-oil-in-water, oil-in-oil, multilayer, and Pickering emulsions can be produced with high encapsulation efficiency of encapsulated materials and narrow size distribution and transformed into structured particles using a variety of different processes, such as polymerisation (suspension, mini-emulsion, interfacial and in-situ), ionic gelation, chemical crosslinking, melt solidification, internal phase separation, layer-by-layer electrostatic deposition, particle self-assembly, complex coacervation, spray drying, sol-gel processing, and molecular imprinting. Particles fabricated from droplets produced by membrane emulsification include nanoclusters, colloidosomes, carbon aerogel particles, nanoshells, polymeric (molecularly imprinted, hypercrosslinked, Janus and core/shell) particles, solder metal powders and inorganic particles. Membrane 2 emulsification devices operate under constant temperature due to low shear rates on the membrane surface, which range from (1−10) × 10 3 s −1 in a direct process to (1−10) × 10 4 s −1 in a premix process.Keywords: Membrane Emulsification; Polymeric microsphere; Microgel; Janus Particle; Core/Shell Particle, Colloidosome. Membrane emulsificationMembrane emulsification (ME) involves preparation of emulsions by pressing a pure dispersed phase or pre-emulsified mixture of the dispersed and continuous phase through a microporous membrane under controlled injection rate and shear conditions. In direct membrane emulsification (DME), one liquid (a dispersed phase) is injected through a microporous membrane into another immiscible liquid (the continuous phase) (Nakashima et al., 1991;, which leads to the formation of droplets at the membrane/continuous phase interface ( Figure 1a). In premix membrane emulsification (PME) (Figure 1b), a pre-emulsion is pressed through the membrane (...

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Microfluidic formulation of pectin microbeads for encapsulation and controlled release of nanoparticles

Cited by 38 publications

References 47 publications

Advanced materials and processing for drug delivery: The past and the future

Advanced materials and processing for drug delivery: The past and the future

A Microfluidic Approach to Encapsulate Living Cells in Uniform Alginate Hydrogel Microparticles

Structured microparticles with tailored properties produced by membrane emulsification

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