Microfluidic paper device with on-site heating to produce reactive peroxide species for enhanced smartphone enabled chemiluminescence signal

Evaluation of food μPADs with the new tech perspectives and future prospects

“…A validated smartphone coupled µPAD achieved a LOD of 1.1 mg/kg for nitrite in meat (Trofimchuk et al, 2020). Another temperature-based approach demonstrated a wide linear range (50 nM to 1 M) and low LOD (35 nM) for H 2 O 2 with lower sample and reagent consumption (Kumar et al, 2022). The inclusion of another adulterant benzoic acid in milk can cause diarrhea, asthma, convulsions, and abdominal pain (Hussain et al, 2020).…”

High sensitivity and automatic chemiluminescence detection of glucose and lactate using a spin-disc paper-based device

“…They can be classified based on the flow control mechanisms into flow injection devices with the differential pressure flow mode, 15 microfluidic paper-based analytical devices (μPADs) driven by capillary force, 16 microchip capillary electrophoresis (MCE) devices using electrokinetic flow, 17 and digital microfluidics (DMF) employing electric fields for droplet control. 18 μPADs have been widely exploited to detect glucose, 19-21 lactate, 16,22 or H 2 O 2 23 using CL due to their advantages in fluid flow control, low cost, and disposability. The capability in fluid flow enabled by the capillary force facilitated the easy control of multiple reagents and reaction sequences on paper devices.…”

“…Numerous paper-based chemiluminescence devices have been developed, with a predominant focus on metabolic markers in food, 23 blood, 20 and urine 21 samples. For instance, Kumar et al developed a 3D printed microfluidic paper-based CL analyzer for H 2 O 2 in milk, which had a LOD of 35 nM and a linear range of 0.05-1 μM.…”

“…μPADs have been widely exploited to detect glucose, 19–21 lactate, 16,22 or H 2 O 2 23 using CL due to their advantages in fluid flow control, low cost, and disposability. The capability in fluid flow enabled by the capillary force facilitated the easy control of multiple reagents and reaction sequences on paper devices.…”

Homemade Paper Analytical Device and Digital Image Colorimetry as Tools for Learning about Calibration Curve Methods during the COVID Pandemic: A Remote vs In-Person Class Evaluation

“…The determination of analytes in paper-based analytical devices (PAD) can be performed using electrochemical, chemiluminescence, electrochemiluminescence, and colorimetric detection. , For this platform, colorimetric detection is of great interest because it is a simple methodology based on chromogenic reactions within the PAD reaction zones. The results can be visually detected by a (i) binary response (positive or negative) in a qualitative approach; (ii) comparison with a colorimetric scale obtained by a standard (semiquantitative approach); or (iii) quantitatively through the use of mathematical models in which the product color intensity is proportional to the chemical species concentration to be quantified from the digitalized image …”