Microfluidic Polymer Chip with an Embedded Ion-Selective Electrode Detector for Nitrate-Ion Assay in Environmental Samples

Abstract

A nitrate ion-selective electrode (NO3 --ISE) has been developed based on tetradodecylammonium bromide as an anion exchanger and 2-nitrophenyl octyl ether as a plasticizer. The NO3 -

A New Microfluidic Polymer Chip with an Embedded Cationic Surfactant Ion-selective Optode as a Detector for the Determination of Cationic Surfactants

“…7,11,12,[14][15][16][17] Next, part B, part C and part D (C is the middle) were sandwiched between two glass plates and pressed by a double clip, and put into an oven at 110 C for 30 min for thermal fusion of parts B, C and D (part E0). A hole was drilled using a 1.05 mm driller at 0.5 cm length and 1 cm width of both sides of part E0 for fabricating a channel of a sample solution and waste (part E).…”

“…[7][8][9][10][11][12][13][14][15][16][17] Among electrochemical detection methods, an ion-selective electrode (ISE) and an ion-sensitive field effect transistor (ISFET) are effective as detection methods of a microfluidic chip. This is because ISE and ISFET are easy to miniaturize and can easily be fabricated at low cost, and the sensitivity of ISE and ISFET does not decrease, even if their size is reduced.…”

“…This is because ISE and ISFET are easy to miniaturize and can easily be fabricated at low cost, and the sensitivity of ISE and ISFET does not decrease, even if their size is reduced. [10][11][12][13][14][15][16][17] We have already developed a new microfluidic polymer chip with an embedded ISE, where a channel on the chip was prepared by using a small-diameter wire as a template of the channel. 11,12,[14][15][16][17] On the other hand, ion-selective optical sensor (Optode) membranes are suited for a detector of microfluidic chips, compared with the ISE and the ISFET.…”

“…[10][11][12][13][14][15][16][17] We have already developed a new microfluidic polymer chip with an embedded ISE, where a channel on the chip was prepared by using a small-diameter wire as a template of the channel. 11,12,[14][15][16][17] On the other hand, ion-selective optical sensor (Optode) membranes are suited for a detector of microfluidic chips, compared with the ISE and the ISFET. [18][19][20][21][22][23][24] From the viewpoints of applications to microfluidic technology, optodes are superior to ISEs because they are not subject to electrical noise, and no contacts to microfluidic chips are required for measurements.…”

Sequential Injection Analysis of Anionic Surfactants Using On-line Preconcentration Technique and a Microfluidic Polymer Chip with an Embedded Ion-Selective Electrode as a Detector

“…The microfluidic chip technology [25][26][27][28][29][30][31][32] is paid much attention in the field of chemistry and biochemistry because it has excellent advantages of lower consumption of reagents and lower sample volumes. Potentiometry using ISEs and FETs has been considered to be one of an excellent detection method in microfluidic chips because the sensitivity of ISEs and FETs does not change with their size and as the result, ISEs and FETs are very easy to miniaturize with keeping the sensitivity.…”