Microfluidics: A New Layer of Control for Extrusion-Based 3D Printing

Serex, Ludovic; Bertsch, Arnaud; Renaud, Philippe

doi:10.3390/mi9020086

Cited by 55 publications

(49 citation statements)

References 58 publications

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“…Methods like flow focusing (images in the middle) can be also applied to 3D printing and help reducing filament diameters. Reproduced under the terms of the Creative Commons CC‐BY 4.0 License ( https://creativecommons.org/licenses/by/4.0/) . Copyright 2018, The Authors, Published by MDPI.…”

Section: Recent Progress For Controlling Shapementioning

confidence: 99%

“…The microfluidic bioprinting systems can precisely manipulate the behavior of liquids at microscale level and offer a promising solution to accurately control the deposition of, so far, up to seven materials . Each material has its own inlet to a microchannel in a microfluidic chip or nozzle.…”

Section: Recent Progress For Controlling Shapementioning

confidence: 99%

Section: Coaxial Printingmentioning

confidence: 99%

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From Shape to Function: The Next Step in Bioprinting

et al. 2020

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In 2013, the “biofabrication window” was introduced to reflect the processing challenge for the fields of biofabrication and bioprinting. At that time, the lack of printable materials that could serve as cell‐laden bioinks, as well as the limitations of printing and assembly methods, presented a major constraint. However, recent developments have now resulted in the availability of a plethora of bioinks, new printing approaches, and the technological advancement of established techniques. Nevertheless, it remains largely unknown which materials and technical parameters are essential for the fabrication of intrinsically hierarchical cell–material constructs that truly mimic biologically functional tissue. In order to achieve this, it is urged that the field now shift its focus from materials and technologies toward the biological development of the resulting constructs. Therefore, herein, the recent material and technological advances since the introduction of the biofabrication window are briefly summarized, i.e., approaches how to generate shape, to then focus the discussion on how to acquire the biological function within this context. In particular, a vision of how biological function can evolve from the possibility to determine shape is outlined.

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Section: Recent Progress For Controlling Shapementioning

confidence: 99%

Section: Recent Progress For Controlling Shapementioning

confidence: 99%

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From Shape to Function: The Next Step in Bioprinting

et al. 2020

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“…Extrusion-based printing widely applied in metal printing, polymer printing, and bioprinting ( Figure 5) (Ning and Chen, 2017). The printing techniques have been recently developed to precision extrusion deposition (PED) (Fedore et al, 2017), precise extrusion manufacturing (PEM) (Jamroz et al, 2018), and multiple heads deposition extrusion (MHDS) (Serex et al, 2018). Multiple bioprinting applications in vascular models, soft-tissue models, and bone models manufactured with extrusion-based printing technology have been well-developed in recent years (Ahlfeld et al, 2017;Paxton et al, 2017;Ahlfeld et al, 2018).…”

Section: Extrusion-based Printingmentioning

confidence: 99%

Progressive 3D Printing Technology and Its Application in Medical Materials

et al. 2020

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Three-dimensional (3D) printing enables patient-specific anatomical level productions with high adjustability and resolution in microstructures. With cost-effective manufacturing for high productivity, 3D printing has become a leading healthcare and pharmaceutical manufacturing technology, which is suitable for variety of applications including tissue engineering models, anatomical models, pharmacological design and validation model, medical apparatus and instruments. Today, 3D printing is offering clinical available medical products and platforms suitable for emerging research fields, including tissue and organ printing. In this review, our goal is to discuss progressive 3D printing technology and its application in medical materials. The additive overview also provides manufacturing techniques and printable materials.

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“…Micro/nanopatterns with micro deposition techniques have been used in various applications such as flexible electronic devices, microfluidics [1]- [4], biological tissue engineering [5], surface micromachining [6], pharmaceutical application [7]- [8], dispersive liquid-liquid microextraction [9]- [10], bioprinting sensing [11], etc. For depositing a small size of droplets that can be controlled, structured and patterned precisely is a very important process for micro fabrication.…”

Section: Introductionmentioning

confidence: 99%

Programmable Syringe Pump for Selective Micro Droplet Deposition

Kurniawan¹,

Adam

Salik³

et al. 2019

indones.j.electron.telecommun.

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Micro/nanopatterns with micro deposition techniques have been used in various applications such as flexible electronic devices, biosensing, and biological tissue engineering. For depositing a small size of droplets that can be controlled, structured and patterned precisely is a very important process for microfabrication. In this study, we developed a low cost and simple system for fabricating micro/nanostructure by a selective micro deposition process using a syringe pump. This method is an additive fabrication method where selective droplet materials are released through a needle of the syringe pump. By translating the rotating stepper motor into a linear movement of the lead screw, it will press the plunger of the syringe and give a force to the fluid inside the syringe, hence a droplet can be injected out. The syringe pump system consists of a syringe, the mechanical unit, and the controller unit. A stepper motor, the lead screw, and the mechanical components are used for the mechanical unit. Arduino Uno microcontroller is used as the controller unit and can be programmed by the computer through GUI (Graphical User Interface). The input parameters, such as the push or pull of flow direction, flow rate, the droplet volume, and syringe size dimension can be inputted by the user as their desired value via keypad or the computer. The measurement results show that the syringe pump has characteristics: the maximum average error value of the measured volume is 2.5% and the maximum average error value of the measured flow rate is 14%. The benefits of a syringe pump for micro deposition can overcome photolithography weaknesses, which require an etching and stencil process in the manufacture of semiconductors. Combining two or more syringes into one system with different droplet materials can be used as a promising method for 3D microfabrication in the future.

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Microfluidics: A New Layer of Control for Extrusion-Based 3D Printing

Cited by 55 publications

References 58 publications

From Shape to Function: The Next Step in Bioprinting

From Shape to Function: The Next Step in Bioprinting

Progressive 3D Printing Technology and Its Application in Medical Materials

Programmable Syringe Pump for Selective Micro Droplet Deposition

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