Microfluidics: Rapid Diagnosis for Breast Cancer

Panesar, Satvinder; Neethirajan, Suresh

doi:10.1007/s40820-015-0079-8

Cited by 21 publications

(10 citation statements)

References 115 publications

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“…By constructing multiple channels and modifying each channel with a different antibody, it is possible to detect multiple targets simultaneously. The combination of microfluidics technology and biosensing enables biosensors to detect multiple markers simultaneously [ 5 , 117 , 118 ].…”

Section: New Strategies For Biosensormentioning

confidence: 99%

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A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Hong

Sun

et al. 2022

Life

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Breast cancer has the highest cancer incidence rate in women. Early screening of breast cancer can effectively improve the treatment effect of patients. However, the main diagnostic techniques available for the detection of breast cancer require the corresponding equipment, professional practitioners, and expert analysis, and the detection cost is high. Tumor markers are a kind of active substance that can indicate the existence and growth of the tumor. The detection of tumor markers can effectively assist the diagnosis and treatment of breast cancer. The conventional detection methods of tumor markers have some shortcomings, such as insufficient sensitivity, expensive equipment, and complicated operations. Compared with these methods, biosensors have the advantages of high sensitivity, simple operation, low equipment cost, and can quantitatively detect all kinds of tumor markers. This review summarizes the biosensors (2013–2021) for the detection of breast cancer biomarkers. Firstly, the various reported tumor markers of breast cancer are introduced. Then, the development of biosensors designed for the sensitive, stable, and selective recognition of breast cancer biomarkers was systematically discussed, with special attention to the main clinical biomarkers, such as human epidermal growth factor receptor-2 (HER2) and estrogen receptor (ER). Finally, the opportunities and challenges of developing efficient biosensors in breast cancer diagnosis and treatment are discussed.

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Section: New Strategies For Biosensormentioning

confidence: 99%

“…As a result, these methods are difficult to generalize to the majority of people who need this screening, especially for those with early-stage breast cancer that has not yet been detected. Compared with the above methods, the detection of the tumor markers of breast cancer using a biosensor is a more efficient and less costly [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Hong

Sun

et al. 2022

Life

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“…Microfluidic devices have many advantages, including their high throughput, low cost, miniaturization, quick analysis, high sensitivity, precise operation, high efficiency, portability, low sample consumption, and accuracy [28][29][30][31][32][33][34]. As the name implies, microfluidics is concerned with accurate fluid flow management in microliters to picoliters (10)(11)(12) within micro-volume channels [35]. Various techniques like 3D printing [36], molding, laminating, and high-resolution nanofabrication are used to create these devices.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Microfluidic Platform for Physical and Immunological Detection and Capture of Circulating Tumor Cells

et al. 2022

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CTCs (circulating tumor cells) are well-known for their use in clinical trials for tumor diagnosis. Capturing and isolating these CTCs from whole blood samples has enormous benefits in cancer diagnosis and treatment. In general, various approaches are being used to separate malignant cells, including immunomagnets, macroscale filters, centrifuges, dielectrophoresis, and immunological approaches. These procedures, on the other hand, are time-consuming and necessitate multiple high-level operational protocols. In addition, considering their low efficiency and throughput, the processes of capturing and isolating CTCs face tremendous challenges. Meanwhile, recent advances in microfluidic devices promise unprecedented advantages for capturing and isolating CTCs with greater efficiency, sensitivity, selectivity and accuracy. In this regard, this review article focuses primarily on the various fabrication methodologies involved in microfluidic devices and techniques specifically used to capture and isolate CTCs using various physical and biological methods as well as their conceptual ideas, advantages and disadvantages.

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“…In the early 1990s, Manz et al first verified that electrophoretic separations in a micro total analysis system (µ‐TAS) is more efficient than conventional electrophoresis . Since then, microfluidics has been considered as a promising technique to miniaturize the bulk of conventional equipment . For instance, Quake and co‐workers reported a large‐scale integrated microfluidic chip in 2002 .…”

Section: Microfluidicsmentioning

confidence: 99%

“…[67] Since then, microfluidics has been considered as a promising technique to miniaturize the bulk of conventional equipment. [68,69] For instance, Quake and co-workers reported a large-scale integrated microfluidic chip in 2002. [70] This large-scale integrated microfluidic chip enabled analysis of the expression of a particular enzyme.…”

Section: Microfluidicsmentioning

confidence: 99%

Progress in Microfluidics‐Based Exosome Separation and Detection Technologies for Diagnostic Applications

Lin

Chen

et al. 2019

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245

182

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Exosomes are secreted by most cell types and circulate in body fluids. Recent studies have revealed that exosomes play a significant role in intercellular communication and are closely associated with the pathogenesis of disease. Therefore, exosomes are considered promising biomarkers for disease diagnosis. However, exosomes are always mixed with other components of body fluids. Consequently, separation methods for exosomes that allow high‐purity and high‐throughput separation with a high recovery rate and detection techniques for exosomes that are rapid, highly sensitive, highly specific, and have a low detection limit are indispensable for diagnostic applications. For decades, many exosome separation and detection techniques have been developed to achieve the aforementioned goals. However, in most cases, these two techniques are performed separately, which increases operation complexity, time consumption, and cost. The emergence of microfluidics offers a promising way to integrate exosome separation and detection functions into a single chip. Herein, an overview of conventional and microfluidics‐based techniques for exosome separation and detection is presented. Moreover, the advantages and drawbacks of these techniques are compared.

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Microfluidics: Rapid Diagnosis for Breast Cancer

Cited by 21 publications

References 115 publications

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Recent Advances in Microfluidic Platform for Physical and Immunological Detection and Capture of Circulating Tumor Cells

Progress in Microfluidics‐Based Exosome Separation and Detection Technologies for Diagnostic Applications

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