Microfluidics Technologies and Approaches for Studying the Microcirculation

Murfee, Walter L.; Peirce, Shayn M.

doi:10.1111/micc.12377

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…However, recapitulation of the deep architecture and functioning of the microenvironment underneath the epithelial monolayer has yet to be fully developed. [ 140 ] The intestinal microvasculature is the direct point of access for inflammatory factors on the route to the CNS and is pivotal for microbiota‐peripheral immunity communication. The dual perfused chambers configuration does not allow mechanistic study of molecule exchange phenomena on the abluminal side.…”

Section: Advanced Systems For In Vitro Modelingmentioning

confidence: 99%

“…Therefore, the systems need to be made more complex to include the multiple features of the microcirculation architecture. [ 140 ] Multi‐layer micro‐devices have been developed by using innovative rapid prototyping technologies. [ 141 ] In this manner, the micro‐interface of epithelial and endothelial cells (EC) can be added to the GOC model by tuning thickness of the micrometric intercellular spaces, [ 142 ] and introducing ECM‐like biomaterials in the different layers to resemble the outer ECM, which can significantly modulate the endothelial and epithelial activity.…”

Section: Advanced Systems For In Vitro Modelingmentioning

confidence: 99%

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Microbiota‐Host Immunity Communication in Neurodegenerative Disorders: Bioengineering Challenges for In Vitro Modeling

Boeri

Perottoni

Izzo

et al. 2021

Adv Healthcare Materials

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Human microbiota communicates with its host by secreting signaling metabolites, enzymes, or structural components. Its homeostasis strongly influences the modulation of human tissue barriers and immune system. Dysbiosis‐induced peripheral immunity response can propagate bacterial and pro‐inflammatory signals to the whole body, including the brain. This immune‐mediated communication may contribute to several neurodegenerative disorders, as Alzheimer's disease. In fact, neurodegeneration is associated with dysbiosis and neuroinflammation. The interplay between the microbial communities and the brain is complex and bidirectional, and a great deal of interest is emerging to define the exact mechanisms. This review focuses on microbiota‐immunity‐central nervous system (CNS) communication and shows how gut and oral microbiota populations trigger immune cells, propagating inflammation from the periphery to the cerebral parenchyma, thus contributing to the onset and progression of neurodegeneration. Moreover, an overview of the technological challenges with in vitro modeling of the microbiota‐immunity‐CNS axis, offering interesting technological hints about the most advanced solutions and current technologies is provided.

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Section: Advanced Systems For In Vitro Modelingmentioning

confidence: 99%

Section: Advanced Systems For In Vitro Modelingmentioning

confidence: 99%

Microbiota‐Host Immunity Communication in Neurodegenerative Disorders: Bioengineering Challenges for In Vitro Modeling

Boeri

Perottoni

Izzo

et al. 2021

Adv Healthcare Materials

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Human Microcirculation‐on‐Chip Models in Cancer Research: Key Integration of Lymphatic and Blood Vasculatures

et al. 2020

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Cancer metastasis is a highly complex and multistep process, which is initiated by the invasion of tumor cells into the microcirculation system. A diverse variety of organ‐on‐chip models are described investigating this critical event. However, most of these models solely integrate the blood vasculature and overlook the fundamental role of the lymphatic system despite the solid evidence showing that cancer cells mainly use this vascular network to initiate metastasis. Herein, the latest advances in the field of organ‐on‐chip models of the human microcirculation system in cancer research are reviewed. The reported models are employed to investigate the mechanistic determinants of tumor physiopathology and for the screening of new anticancer drugs under the scope of the microcirculation bed. Overall, the development of complete microcirculation‐on‐chip models integrating the blood and lymphatic vasculatures is expected to provide key insights into the drug delivery process, the screening of novel therapeutic compounds, or the mechanism of tumor invasion and metastasis, among others.

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Microvascular bioengineering: a focus on pericytes

Zhao

Chappell

2019

J Biol Eng

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Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many key features of these capillary networks, with an increasing appreciation for the necessity of incorporating vascular pericytes. Here, we briefly review established and more recent insights into important aspects of pericyte identification and function within the microvasculature. We then consider the importance of including vascular pericytes in various bioengineered microvessel platforms including 3D culturing and microfluidic systems. We also discuss how vascular pericytes are a vital component in the construction of computational models that simulate microcirculation phenomena including angiogenesis, microvascular biomechanics, and kinetics of exchange across the vessel wall. In reviewing these topics, we highlight the notion that incorporating pericytes into microvascular bioengineering applications will increase their utility and accelerate the translation of basic discoveries to clinical solutions for vascular-related pathologies.

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Microfluidics Technologies and Approaches for Studying the Microcirculation

Cited by 3 publications

References 9 publications

Microbiota‐Host Immunity Communication in Neurodegenerative Disorders: Bioengineering Challenges for In Vitro Modeling

Microbiota‐Host Immunity Communication in Neurodegenerative Disorders: Bioengineering Challenges for In Vitro Modeling

Human Microcirculation‐on‐Chip Models in Cancer Research: Key Integration of Lymphatic and Blood Vasculatures

Microvascular bioengineering: a focus on pericytes

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