Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments

Abstract

Plant bioactive compounds are known for their extensive health benefits and therefore have been used for generations in traditional and modern medicine to improve the health of humans. Processing and storage instabilities of the plant bioactive compounds, however, limit their bioavailability and bioaccessibility and thus lead researchers in search of novel encapsulation systems with enhanced stability, bioavailability, and bioaccessibility of encapsulated plant bioactive compounds. Recently many varieties of encapsulation methods have been used; among them, microfluidization has emerged as a novel method used for the development of delivery systems including solid lipid nanocarriers, nanoemulsions, liposomes, and so on with enhanced stability and bioavailability of encapsulated plant bioactive compounds. Therefore, the nanodelivery systems developed using microfluidization techniques have received much attention from the medical industry for their ability to facilitate controlled delivery with enhanced health benefits in the treatment of various chronic diseases. Many researchers have focused on plant bioactive compound-based delivery systems using microfluidization to enhance the bioavailability and bioaccessibility of encapsulated bioactive compounds in the treatment of various chronic diseases. This review focuses on various nanodelivery systems developed using microfluidization techniques and applications in various chronic disease treatments.

Formulation and Preparation of Water-In-Oil-In-Water Emulsions Loaded with a Phenolic-Rich Inner Aqueous Phase by Application of High Energy Emulsification Methods

“…Under suitable homogenization conditions, the final droplet size depends strongly on the characteristics of the oil and emulsifier used [ 34 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. In general, small droplet sizes can be obtained more effectively by low-energy approaches than by high-energy approaches, but the former are more limited in the types of oils and emulsifiers that can be used [ 11 ].…”

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

“…Successful nanodelivery systems are characterized by optimal features for loading and release of therapeutic agent, long storage life, as well as high therapeutic efficacy with no or minimized side effects (Bilia et al, 2017;Piazzini et al, 2018). Among these nanodelivery systems, there are both solid (nanocrystals, lipid and polymeric nanoparticles) and liquid (including nanoliposomes, nanoemulsions, and nanopolymersomes) ones (Borel and Sabliov, 2014;Ganesan et al, 2018a). These systems are described in details in the subsequent sections.…”

Optimization, Characterization, and Influence of Microfluidization on Almond Gum‐based Composite Edible Film

“…Microfluidization may have led to reduced particle size and enhancing stability, bioavailability, and bioaccessibility of the matrix. [41,51] The increasing concentrations of sunflower oil which got embedded in the film matrix, resulting in a more compact polymer network. [40] Also, it may be noted that surface irregularity had an inverse relationship with the microfluization pressure.…”