Microfracture Technique versus Carbon Fibre Rod Implantation for Treatment of Knee Articular Cartilage Lesions

Daşar, Uygar; Gürsoy, Safa; Akkaya, Mustafa; Algın, Oktay; Işık, Çetin; Bozkurt, Murat

doi:10.1177/1602400214

Cited by 11 publications

(20 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sample size was calculated a priori based on previous studies comparing other cartilage restoration procedures and microfracture. 2,8,21,29 In previous studies, the mean MOCART score at 48 weeks postoperatively was estimated to be 65.5 and 56.1 in the investigational and control groups, respectively. In addition, in previous studies, the highest value of standard deviation of the MOCART score was estimated to be 14.1.…”

Section: Discussionmentioning

confidence: 97%

Particulated Costal Allocartilage With Microfracture Versus Microfracture Alone for Knee Cartilage Defects: A Multicenter, Prospective, Randomized, Participant- and Rater-Blinded Study

Chung

Jung

Jang

et al. 2023

Orthopaedic Journal of Sports Medicine

View full text Add to dashboard Cite

Background: Microfracture is the first-line treatment for cartilage defects; however, the suboptimal quality of the repaired cartilage remains an issue. Purpose/Hypothesis: The aim of this first in-human study was to compare the clinical efficacy and safety of a combination of particulated costal allocartilage and microfracture versus microfracture alone in treating knee cartilage defects. We hypothesized that the particulated costal allocartilage with microfracture would result in superior cartilage repair quality and better clinical outcomes at 48 weeks postoperatively. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Patients with cartilage defects were allocated randomly to the treatment group (particulated costal allocartilage with microfracture) and control group (microfracture alone). Magnetic resonance imaging (MRI) outcomes of cartilage repair (the primary outcome measure) were evaluated at the 48-week follow-up using the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. Patient-reported clinical outcomes (visual analog scale [VAS] pain score, Knee injury and Osteoarthritis Outcome Score [KOOS], and International Knee Documentation Committee score) and adverse events were evaluated at 12, 24, and 48 weeks postoperatively. Results: Overall, 88 patients were included (44 patients each in the treatment and control groups). The total MOCART score at 48 weeks postoperatively was significantly higher in the treatment group than in the control group ( P < .001). Among the 9 MOCART variables, 6 were significantly superior in the treatment versus the control group: degree of repair and defect filling ( P < .001), integration to the border zone ( P < .001), surface ( P = .006), structure ( P = .011), signal intensity of the repair tissue ( P < .001), and subchondral lamina ( P = .005). There were significant between-group differences in KOOS-Pain ( P = .014), KOOS-Activities of Daily Living ( P = .010), KOOS-Sports ( P = .029), and KOOS-Symptoms ( P = .039) at 12 weeks postoperatively and in VAS pain ( P = .012) and KOOS-Pain ( P = .005) at 24 weeks postoperatively. At 48 weeks postoperatively, clinical outcomes were comparable between the groups. Conclusion: Microfracture augmented with particulated costal allocartilage resulted in superior cartilage repair quality compared with microfracture alone in terms of MRI evaluation of the knee joint cartilage defect at the 48-week follow-up. Functional outcomes were favorable for both treatments at final follow-up. Registration: KCT0004936 (Clinical Research Information Service [CRiS] of the Republic of Korea).

show abstract

Section: Discussionmentioning

confidence: 97%

Particulated Costal Allocartilage With Microfracture Versus Microfracture Alone for Knee Cartilage Defects: A Multicenter, Prospective, Randomized, Participant- and Rater-Blinded Study

Chung

Jung

Jang

et al. 2023

Orthopaedic Journal of Sports Medicine

View full text Add to dashboard Cite

show abstract

“…These subgroups were anatomic regions [35,36], anatomic regions for each gender [30], age groups (children and adults) [17] and clinical information like anterior cruciate ligament intact knees and knees with a reconstructed anterior cruciate ligament [22], traumatic and degenerative cartilage defects [37], failure and non-failure of microfracture [31]. Other sub-groups consisted of the method to measure the defects [38] or different operative treatments [26,27,29,32,39,40]. Including all information the lowest mean of cartilage defects was found in the subgroup lateral defects of the study from Everhart, 0.47 cm 2 [36] and the highest mean in the subgroup male with trochlea defects of the study from Kreuz, 9.66 cm 2 [30].…”

Section: Defect Sizementioning

confidence: 99%

Impact of Ear Occlusion on In-Ear Sounds Generated by Intra-oral Behaviors

Nahhas

Gerig

Türp

et al. 2022

Mechanisms and Machine Science

View full text Add to dashboard Cite

translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

show abstract

“…Accumulation of the particles near lymph nodes, slight inflammatory reaction, synovitis, and hypertrophy were also reported. [ 108,109 ] Moreover, discomfort and the loss of knee mobility, and a consistent number of failure determined the limitation of carbon fiber use for tendon/ligament regeneration. [ 108,110 ] Even though carbon fibers were produced “naked” in the beginning, many polymers and copolymers have been utilized as their coatings or protection agents.…”

Section: Fiber‐based Engineered Scaffolds For Tendons and Ligamentsmentioning

confidence: 99%

Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration

Rinoldi

Kijeńska‐Gawrońska

Khademhosseini

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Tendon and ligament injuries caused by trauma and degenerative diseases are frequent and affect diverse groups of the population. Such injuries reduce musculoskeletal performance, limit joint mobility, and lower people's comfort. Currently, various treatment strategies and surgical procedures are used to heal, repair, and restore the native tissue function. However, these strategies are inadequate and, in some cases, fail to re‐establish the lost functionality. Tissue engineering and regenerative medicine approaches aim to overcome these disadvantages by stimulating the regeneration and formation of neotissues. Design and fabrication of artificial scaffolds with tailored mechanical properties are crucial for restoring the mechanical function of tendons. In this review, the tendon and ligament structure, their physiology, and performance are presented. On the other hand, the requirements are focused for the development of an effective reconstruction device. The most common fiber‐based scaffolding systems are also described for tendon and ligament tissue regeneration like strand fibers, woven, knitted, braided, and braid‐twisted fibrous structures, as well as electrospun and wet‐spun constructs, discussing critically the advantages and limitations of their utilization. Finally, the potential of multilayered systems as the most effective candidates for tendon and ligaments tissue engineering is pointed out.

show abstract

Microfracture Technique versus Carbon Fibre Rod Implantation for Treatment of Knee Articular Cartilage Lesions

Abstract: Microfracture is superior to carbon fibre rod implantation in terms of clinical and radiological outcome.

Cited by 11 publications

References 21 publications

Particulated Costal Allocartilage With Microfracture Versus Microfracture Alone for Knee Cartilage Defects: A Multicenter, Prospective, Randomized, Participant- and Rater-Blinded Study

Particulated Costal Allocartilage With Microfracture Versus Microfracture Alone for Knee Cartilage Defects: A Multicenter, Prospective, Randomized, Participant- and Rater-Blinded Study

Impact of Ear Occlusion on In-Ear Sounds Generated by Intra-oral Behaviors

Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration

Contact Info

Product

Resources

About