Microgels With Electrostatically Controlled Molecular Affinity to Direct Morphogenesis
Sebastian Kühn,
Valentina Magno,
Ralf Zimmermann
et al.
Abstract:Concentration gradients of soluble signaling molecules—morphogens—determine the cellular organization in tissue development. Morphogen‐releasing microgels have shown potential to recapitulate this principle in engineered tissue constructs, however, with limited control over the molecular cues in space and time. Inspired by the functionality of sulfated glycosaminoglycans (sGAGs) in morphogen signaling in vivo, a library of sGAG‐based microgels is developed and designated as µGel Units to Instruct Development (… Show more
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