Microglia activation and inflammation in hippocampus attenuates memory and mood functions during experimentally induced diabetes in rat

Nagayach, Aarti; Bhaskar, Rakesh; Patro, Nisha

doi:10.1016/j.jchemneu.2022.102160

Cited by 12 publications

(4 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, the only data available about the impact of short-term experimental T1DM on memory function have been obtained in male animals. The literature data also indicate that, in agreement with what is herein reported, in male animals, the memory impairment induced by STZ injection is associated with neuroinflammatory patterns and alterations in synaptic proteins in the hippocampus [ 27 , 78 , 79 , 80 ]. On the other side, oxidative stress [ 79 , 81 , 82 , 83 ] and altered mitochondrial functionality were reported in the male hippocampus [ 46 , 84 , 85 ], suggesting different mechanisms in the two sexes possibly related to the decrease in memory abilities.…”

Section: Discussionsupporting

confidence: 89%

Diabetic Encephalopathy in a Preclinical Experimental Model of Type 1 Diabetes Mellitus: Observations in Adult Female Rat

Falvo

Giatti

Diviccaro

et al. 2023

IJMS

View full text Add to dashboard Cite

Patients affected by diabetes mellitus (DM) show diabetic encephalopathy with an increased risk of cognitive deficits, dementia and Alzheimer’s disease, but the mechanisms are not fully explored. In the male animal models of DM, the development of cognitive impairment seems to be the result of the concomitance of different processes such as neuroinflammation, oxidative stress, mitochondrial dysfunction, and aberrant synaptogenesis. However, even if diabetic encephalopathy shows some sex-dimorphic features, no observations in female rats have been so far reported on these aspects. Therefore, in an experimental model of type 1 DM (T1DM), we explored the impact of one month of pathology on memory abilities by the novel object recognition test and on neuroinflammation, synaptogenesis and mitochondrial functionality. Moreover, given that steroids are involved in memory and learning, we also analysed their levels and receptors. We reported that memory dysfunction can be associated with different features in the female hippocampus and cerebral cortex. Indeed, in the hippocampus, we observed aberrant synaptogenesis and neuroinflammation but not mitochondrial dysfunction and oxidative stress, possibly due to the results of locally increased levels of progesterone metabolites (i.e., dihydroprogesterone and allopregnanolone). These observations suggest specific brain-area effects of T1DM since different alterations are observed in the cerebral cortex.

show abstract

Section: Discussionsupporting

confidence: 89%

Diabetic Encephalopathy in a Preclinical Experimental Model of Type 1 Diabetes Mellitus: Observations in Adult Female Rat

Falvo

Giatti

Diviccaro

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…In this task, the animal learns to find the baited arm based on their memory retrieval ability regarding the previously visited arm and chooses the opposite arm to obtain a food reward. We performed the T-maze test as previously described in [ 76 , 79 ], with some modifications. Briefly, two days prior to the experiment, rats were deprived of ad libitum food (85%).…”

Section: Methodsmentioning

confidence: 99%

Impaired Insulin Signaling Alters Mediators of Hippocampal Synaptic Dynamics/Plasticity: A Possible Mechanism of Hyperglycemia-Induced Cognitive Impairment

Ansari

Al-Jarallah

Babiker

2023

Cells

View full text Add to dashboard Cite

show abstract

“…There is growing evidence that DM-related chronic in ammation can activate microglia, the resident immune cells of the central nervous system (CNS) [10][11][12]. In vitro studies have shown that under chronic hyperglycemia, microglia became activated showing enlarged cell bodies, enhanced migration and phagocytosis as well as increased production of pro-in ammatory factors [10,13,14]. However, the exact contribution of microglia to DM-related abnormalities of the brain functions remain poor understood.…”

Section: Introductionmentioning

confidence: 99%

Transcranial photobiomodulation improves insulin therapy in diabetic mice: modulation of microglia and the brain drainage system

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: The chronic hyperglycemia of diabetes mellitus (DM) leads to the dysfunction of microglia, which is associated with the occurrence of diabetic cerebrovascular injuries (DCIs) and various complications, the main reasons of death in patients with DM. Although long term insulin therapy can effectively control blood glucose levels, it is not sufficient to rapidly restore the function of microglia. Therefore, the search for new alternative methods of treating diabetes-related dysfunction of microglia is urgently needed to improve the survival and quality of life of patients with DM. Methods: We evaluated the therapeutic effects of transcranial photobiomodulation (tPBM) at near infrared-Ⅱ wavelengths (1267 nm) with high tissue penetration depth on microglial function in diabetic mice. Afterwards, we investigated the mechanisms of tPBM in terms of changes in blood-brain barrier permeability and meningeal lymphatic vessels function. Results: The treatment of tPBM significantly improved insulin therapy via modulation of microglial morphology and reactivity to cerebrovascular injury. We also demonstrated that tPBM stimulated the brain drainage system through activation of the meningeal lymphatics contributing the removal of inflammatory factor, such as the interferon gamma (IFN-γ) from the brain parenchyma. These therapeutic effects of tPBM contribute the repair of microglial reactivity to the cerebrovascular injury via an increase in the expression of microglial chemokine receptor P2RY12. Conclusions: Our results demonstrate that tPBM can be an efficient innovative method for the treatment of microglial dysfunction caused by diabetes to prevent diabetic brain disorders and has the potential to be quickly introduced in clinical practice since tPBM is widely used for the therapy of brain diseases.

show abstract

Microglia activation and inflammation in hippocampus attenuates memory and mood functions during experimentally induced diabetes in rat

Cited by 12 publications

References 94 publications

Diabetic Encephalopathy in a Preclinical Experimental Model of Type 1 Diabetes Mellitus: Observations in Adult Female Rat

Diabetic Encephalopathy in a Preclinical Experimental Model of Type 1 Diabetes Mellitus: Observations in Adult Female Rat

Impaired Insulin Signaling Alters Mediators of Hippocampal Synaptic Dynamics/Plasticity: A Possible Mechanism of Hyperglycemia-Induced Cognitive Impairment

Transcranial photobiomodulation improves insulin therapy in diabetic mice: modulation of microglia and the brain drainage system

Contact Info

Product

Resources

About