Microglia and Chitotriosidase in Multiple Sclerosis

Sotgiu, Stefano; Musumeci, Salvatore; Marconi, Silvia; Bonetti, Bruno

doi:10.17925/enr.2008.03.02.90

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…It has been suggested that CHIT1 has a role in the defense towards chitin containing pathogens [19] however elevated expression of CHIT1 has also been associated with a range of human diseases that have no obvious connection to chitin containing pathogens. These include Gaucher type I disease [20], Alzheimer's disease [21][22][23], type B Niemann-Pick disease [24], sarcoidosis [25,26], atherosclerosis [27], multiple sclerosis [28,29] and scleroderma-associated lung disease where CHIT1 has even been proposed as a potential therapeutic target [30]. The specific effects of the CHIT1 in these diseases are not known.…”

Section: Discussionmentioning

confidence: 99%

Human chitotriosidase CHIT1 cross reacts with mammalian‐like substrates

Larsen¹,

Yoshimura²,

Voldborg³

et al. 2014

FEBS Letters

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a b s t r a c tHumans do not synthesize chitin, yet they produce a number of active and inactive chitinases. One of the active enzymes is chitotriosidase whose serum levels are elevated in a number of diseases such as Gaucher's disease and upon fungal infection. Since the biological role of chitotriosidase in disease pathogenesis is not understood we screened a panel of mammalian GlcNAc-containing glycoconjugates as alternate substrates. LacNAc and LacdiNAc-terminating substrates are hydrolyzed, the latter with a turnover comparable to that of pNP-chitotriose. Glycolipids or glycoproteins with LacNAc and LacdiNAc represent potential chitinase substrates and the subsequent alteration of glycosylation pattern could be a factor in disease pathogenesis.

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