2023
DOI: 10.1101/2023.10.06.561235
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Microglia facilitate and stabilize the response to general anesthesia

Yang He,
Taohui Liu,
Quansheng He
et al.

Abstract: General anesthesia leads to a loss of consciousness and an unarousable state in patients. Although general anesthetics are widely used in clinical practice, their underlying mechanisms remain elusive. The potential involvement of nonneuronal cells is unknown. Microglia are important immune cells in the central nervous system (CNS) that play critical roles in CNS function and dysfunction. We unintentionally observed delayed anesthesia induction and early anesthesia emergence in microglia-depleted mice. We found… Show more

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