Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence

Abstract

Poststroke depression (PSD) does not exist before and occurs after the stroke. PSD can appear shortly after the onset of stroke or be observed in the weeks and months after the acute or subacute phase of stroke. The pathogenesis of PSD is unclear, resulting in poor treatment effects. With research advancement, immunoactive cells in the central nervous system, particularly microglia, play a role in the occurrence and development of PSD. Microglia affects the homeostasis of the central nervous system through various factors, leading to the occurrence of depression. The research progress of microglia in PSD has been summarized to review the evidence regarding the pathogenesis and treatment target of PSD in the future.

Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

“…Furthermore, a significant correlation between CNS inflammation and peripheral inflammation is also supported ( Leng et al, 2018 ; Richards et al, 2018 ). It is worth noting that inflammation of the CNS is closely associated with microglia and astrocytes, and there has been a lot of evidence that inflammatory microglia and astrocytes play an important role in the development of depression ( Rajkowska and Stockmeier, 2013 ; Peng et al, 2015 ; Leng et al, 2018 ; Xia W. et al, 2022 ; Xie et al, 2022 ).…”

Retracted: Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”