Microglia phagocytose alloreactive CTL-damaged 9L gliosarcoma cells

Kulprathipanja, Nisha V.; Kruse, Carol A.

doi:10.1016/j.jneuroim.2004.04.011

Cited by 19 publications

(16 citation statements)

References 41 publications

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“…Thus microglia can limit lymphocytes and it intends to damage transformed cells by FasL, but in turn, this FasL expression on microglia destroys lymphocytes in its vicinity. In adoptive transfer of alloreactive cytotoxic T cells of rat 9L gliosarcoma, CTL damaged cells are removed by phagocytic scavenging [47,48]. Phosphatidylserine (PS) externalization occurs in damaged/apoptotic rat glioma cells, which signals microglia to clear those cellular corps.…”

Section: Microglia Wrestles Against Neuroimmune Suppression By Gliomamentioning

confidence: 99%

Microglial action in glioma: A boon turns bane

Ghosh¹,

Chaudhuri²

2010

Immunology Letters

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Section: Microglia Wrestles Against Neuroimmune Suppression By Gliomamentioning

confidence: 99%

Microglial action in glioma: A boon turns bane

Ghosh¹,

Chaudhuri²

2010

Immunology Letters

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“…Although the etiology of brain and central nervous system tumors is largely unknown, several lines of evidence indicate that events that alter antitumor T cell responses could be important (Gomez and Kruse 2006;Kulprathipanja and Kruse 2004;Carson et al 1999;Aloisi et al 1998;Schartner et al 2005). The results suggest that the CTLA4 A49G genotype is significantly related to glioma risk, especially in males and children in the Chinese population.…”

Section: Discussionmentioning

confidence: 99%

CTLA4 A49G Polymorphism Shows Significant Association With Glioma Risk in a Chinese Population

Zhan

Dou

et al. 2010

Biochem Genet

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Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) A49G is a polymorphism that is extensively studied in various cancers. To investigate whether it is associated with the occurrence of glioma in Chinese patients, we performed a case-control research study with 670 patients and 680 controls. In this group, we found that the genotype at this locus is significantly associated with glioma risk (GG vs. AA: P = 0.045; GG + AG vs. AA: P = 0.013). In some subgroups, G allele carriers are significantly less represented. We also observed significant correlations between the polymorphism genotype and glioma risk in patients with WHO histologic stages. We conclude that CTLA4 A49G might be a potential clinical biomarker for distinguishing persons with a high risk for developing gliomas.

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“…This report is the first to demonstrate that γδ T lymphocytes purified isolated from BCG vaccinated pigs lyse M. bovis-infected microglia. The cytolytic activity demonstrated may be an important response for the control of M. bovis-infected microglia as well as the control of the growth of the bacilli through the mediators granulysin and perforins, both capable of lysing Mycobacterium (Kulpathipania and Kruse 2004;Poluektova et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Morphine Alters M. bovis Infected Microglia’s Ability to Activate γδ T Lymphocytes

Olin

Choi

Molitor

2011

J Neuroimmune Pharmacol

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Microglia, the macrophages of the central nervous system (CNS), are both the principle target cells for Mycobacterium infection in the CNS and serve a critical role in defense of the brain. If microglia's functions are altered due to immunosuppressive agents such as opiates, perturbation in defense of the brain may occur, including defense against CNS Tuberculosis. This study was designed to determine if Mycobacterium infected microglia activate γδT lymphocytes and if the opiate morphine alters the capability of microglia to activate γδT lymphocytes. γδT lymphocytes proliferated, produced IFN-γ, and demonstrated cytolytic response upon exposure to Mycobacterium bovis infected microglia. IFN-γ, and antigen specific cytotoxicity were both markedly impaired due to morphine treatment.

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Microglia phagocytose alloreactive CTL-damaged 9L gliosarcoma cells

Cited by 19 publications

References 41 publications

Microglial action in glioma: A boon turns bane

Microglial action in glioma: A boon turns bane

CTLA4 A49G Polymorphism Shows Significant Association With Glioma Risk in a Chinese Population

Morphine Alters M. bovis Infected Microglia’s Ability to Activate γδ T Lymphocytes

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