2024
DOI: 10.1101/2024.05.07.592939
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Microglia regulate motor neuron plasticity via reciprocal fractalkine/adenosine signaling

Alexandria B. Marciante,
Arash Tadjalli,
Kayla A. Burrowes
et al.

Abstract: Microglia are innate CNS immune cells that play key roles in supporting key CNS functions including brain plasticity. We now report a previously unknown role for microglia in regulating neuroplasticity within spinal phrenic motor neurons, the neurons driving diaphragm contractions and breathing. We demonstrate that microglia regulate phrenic long-term facilitation (pLTF), a form of respiratory memory lasting hours after repetitive exposures to brief periods of low oxygen (acute intermittent hypoxia; AIH) via n… Show more

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