DOI: 10.18130/v3h31c
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Microglial LRP1 modulates neuroinflammation via control of the NF-κB pathway in autoimmunity

Abstract: Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS), characterized by immune cell infiltration and inflammation.While T cells are known contributors to MS pathology, the precise function of CNS resident and peripheral infiltrating myeloid cells is more controversial. In this work I delineate the myeloid cell function of LRP1, a scavenger receptor crucial for myelin clearance and the inflammatory response, in the context of MS. I find that LRP1 expression is incr… Show more

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