Microinflammation Factors in the Common Diseases of the Heart and Kidneys

Tasić, Danijela; Radenković, Sonja; Kocić, Gordana; Ilic, M. Deljanin; Ignjatović, Aleksandra

doi:10.1155/2015/470589

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…There is evidence that cognitive decline occurs in great apes. 9,10,139,252 In aged chimpanzees and orangutans, only certain types of tasks were affected—such as social cognition, some motor skills, and, in the case of orangutans and gorillas, relative numerousness judgment.…”

Section: Nervous System Disordersmentioning

confidence: 99%

Comparative Pathology of Aging Great Apes

2015

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The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives. Despite the many similarities, there are significant differences in aging among apes, including the human ape. Common to all are dental attrition, periodontitis, tooth loss, osteopenia, and arthritis, although gout is uniquely human and spondyloarthropathy is more prevalent in apes than humans. Humans are more prone to frailty, sarcopenia, osteoporosis, longevity past reproductive senescence, loss of brain volume, and Alzheimer dementia. Cerebral vascular disease occurs in both humans and apes. Cardiovascular disease mortality increases in aging humans and apes, but coronary atherosclerosis is the most significant type in humans. In captive apes, idiopathic myocardial fibrosis and cardiomyopathy predominate, with arteriosclerosis of intramural coronary arteries. Similar cardiac lesions are occasionally seen in wild apes. Vascular changes in heart and kidneys and aortic dissections in gorillas and bonobos suggest that hypertension may be involved in pathogenesis. Chronic kidney disease is common in elderly humans and some aging apes and is linked with cardiovascular disease in orangutans. Neoplasms common to aging humans and apes include uterine leiomyomas in chimpanzees, but other tumors of elderly humans, such as breast, prostate, lung, and colorectal cancers, are uncommon in apes. Among the apes, chimpanzees have been best studied in laboratory settings, and more comparative research is needed into the pathology of geriatric zoo-housed and wild apes. Increasing longevity of humans and apes makes understanding aging processes and diseases imperative for optimizing quality of life in all the ape species.

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Section: Nervous System Disordersmentioning

confidence: 99%

Comparative Pathology of Aging Great Apes

2015

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“…Decrease of glomerular filtration rate (GFR) increases the level of molecules which are markers of hemostasis. In addition, impaired renal function contributes to the formation of prothrombotic condition indirectly through the electrolyte disturbances and acid-base status influencing the change of activity of the enzyme coagulation [11]. It was found that atherosclerosis and risk of cardiovascular disease are associated with inflammation and procoagulant state.…”

Section: Fybrinolitic System and Kidney Diseasementioning

confidence: 99%

Pai -1 Inhibitor as Biomarker of Cardiorenal Damage

Tasić

Tasic

2020

FU Med Biol

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Plasminogen activator inhibitor 1 (PAI-1), which belongs to the family of serine protease inhibitors is the primary regulator of plasminogen activity. PAI-1 is synthesized as a single-chain glycopeptide and is deposited in the platelets in a latent form, from which it is released upon their activation. It is spontaneously converted into stable molecules, unless it reacts with proteins from the plasma. As a powerful inhibitor of fibrinolysis, it participates in the pathogenesis of endothelial damage, processes of accelerated atherosclerosis and thromboembolism. All the diseases of the cardiovascular system which are dominated by the processes of fibrosis and thrombosis lead to an increase in PAI-1 in the circulation. In the emergence and development of atherosclerosis, it plays a role not only in the formation of intraluminal thrombus but also in neointimal proliferation. PAI-1 is not normally present in kidney tissue, but its concentration increases significantly in its acute and chronic kidney disease, thanks to the synthesis by the intrarenally localized inflammatory cells. In addition to genetic predisposition, the factors that directly influence the production of PAI-1 are the following: glycemia, insulin and various neurohumoral factors. It is not normally present in the kidney tissue, but its intrarenal concentration increases significantly in acute and chronic kidney diseases. Numerous studies have confirmed the significant role of PAI-1 in the development of diabetes complications. During the last decade there has been a growth of interest in the introduction of non-invasive methods or biomarkers that would assess the degree of fibrosis in the kidney. Many studies have confirmed association between kidney and heart disease. It is not only that these diseases share common risk factors, but many other mechanisms have been suggested. Plasminogen activator inhibitor -1 plays a role in the pathogenesis of endothelial damage, processes of fibrosis and thrombosis, development of diabetes complications and acute and chronic kidney diseases.

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“…Today, it is considered that IL-8 also has an indirect role in the processes of renal fibrogenesis (Lane, 2013). Clinical studies in dialysis patients have shown that IL-8 plays the role of a predictor for cardiovascular events (Tasic et al, 2015;Nymo et al, 2017). PAI-1 is synthesized as a single-chain glycopeptide and is deposited in the platelets in a latent form, from which it is released on their activation.…”

Section: Introductionmentioning

confidence: 99%

Markers of the progression of kidney damage analyzed by soft computing approach

Tasić

2018

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Purpose The purpose of this study is to analyze markers of the progression of kidney damage by a soft computing approach. Design/methodology/approach Because markers of the progression of kidney damage, namely, plasminogen activator inhibitor-1 (PAI-1), interleukin-8 (IL-8) and highly sensitive troponin T (cTnhsT), are complex parameters, a soft computing approach was used for the assessment of functional glomerular reserves, through the use of the Modification of the Diet in Renal Disease (MDRD) formula based on serum creatinine and EPI creatinine-cystatin C formula (chronic kidney disease epidemiology collaboration). Findings The soft computing approach was used to detect which factors (PAI-1, IL-8 and cTnhsT) are the most important for the MDRD formula based on serum creatinine or the EPI creatinine–cystatin C formula. Originality/value Markers of the progression of kidney damage were analyzed by the soft computing approach.

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Microinflammation Factors in the Common Diseases of the Heart and Kidneys

Cited by 8 publications

References 30 publications

Comparative Pathology of Aging Great Apes

Comparative Pathology of Aging Great Apes

Pai -1 Inhibitor as Biomarker of Cardiorenal Damage

Markers of the progression of kidney damage analyzed by soft computing approach

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