Microinvasive Paget's disease

The role of sentinel lymph node biopsy in the management of invasive extramammary Paget's disease: Multi-center, retrospective study of 151 patients

“…Compared to those with negative SLN, patients with positive SLN had more advanced primary tumor, nodule in the primary lesion (p = 0.0029), invasion into the reticular dermis or deeper (p = 0.0040), and lymphovascular invasion (p < 0.0001). Although most of the patients with positive SLN had invasion deeper than the reticular dermis, 3 (5%) of the 61 patients with microdermal invasion had positive SLN, indicating that LN metastasis may develop even from the early stage of invasion as observed in a previous report [11].…”

Clinicopathological study of invasive extramammary Paget’s disease: subgroup comparison according to invasion depth

“…3,9,13 Nodal metastasis has been reported in a few cases with minimal invasion. 14,15 In this study, 2 ⁄ 26 (7.7%) patients with minimally invasive EMPD revealed lymph node metastasis. Thus, even though the frequency of nodal metastasis is relatively low in minimally invasive EMPD, minimal invasion should be detected in order to separate these cases from those with in situ EMPD.…”

“…Although the clinical significance of stromal invasion has been controversial, 12 the early detection of dermal invasion in EMPD is important because invasion of the vessels by tumour cells is related to metastasis, including nodal metastasis and poor prognosis 3,9,13 . Nodal metastasis has been reported in a few cases with minimal invasion 14,15 . In this study, 2/26 (7.7%) patients with minimally invasive EMPD revealed lymph node metastasis.…”

Paget's disease of the vulva: clinicopathologic study of type 1 cases treated at a single institution

“…We collected nine previously published articles that included plural cases of type 1b/1c Paget's disease of the vulva and described the status of lymph node metastasis. Among the accumulated 70 cases including those from the present series, 30% (23/70) had lymph node metastasis (6,(10)(11)(12)(13)16,18,23,25) . Importantly, lymph node metastasis was found even in microinvasive Paget's disease (25,26) .…”