Microinvasive squamous cell cervical carcinoma

Raspagliesi, Francesco; Ditto, Antonino; Solima, Eugenio; Quattrone, Pasquale; Fontanelli, Rosanna; Zanaboni, Flavia; Hanozet, Francesco; Spatti, Gianbattista; Calabrese, Enrico; Carcangiu, Maria L.

doi:10.1016/s1040-8428(03)00130-6

Cited by 22 publications

(15 citation statements)

References 47 publications

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“…The SGO definition does not comment on the width of the lesion. Clinical studies and expert opinion have generally concluded that ''microinvasive'' SCC can be managed conservatively by cervical conization, LEEP excision, or simple hysterectomy, although more restrictive depth criteria of 2 mm or even 1 mm have been proposed or used [98,[100][101][102][103][104][105][106][107][108][109][110][111][112][113].…”

Section: Site-specific Recommendationsmentioning

confidence: 99%

“…Nevertheless, some have adopted the presence of LVI, or ''extensive'' LVI, as an exclusion criterion for conservative management [105,110,111,134]. In contrast, there is an increased prevalence of both lymph node metastases and recurrence after local excision in FIGO IA2, and many studies conclude that local excision alone is inadequate for this group of patients [39,103,118,126,128,130,[134][135][136][137][138].…”

Section: Site-specific Recommendationsmentioning

confidence: 99%

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The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Darragh

Colgan

Cox

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

643

372

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The terminology for human papillomavirus (HPV)–associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend terminology unified across lower anogenital sites. The goal was to create a histopathologic nomenclature system that reflects current knowledge of HPV biology, optimally uses available biomarkers, and facilitates clear communication across different medical specialties. The Lower Anogenital Squamous Terminology (LAST) Project was cosponsored by the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology and included 5 working groups; 3 work groups performed comprehensive literature reviews and developed draft recommendations. Another work group provided the historical background and the fifth will continue to foster implementation of the LAST recommendations. After an open comment period, the draft recommendations were presented at a consensus conference attended by LAST work group members, advisors, and representatives from 35 stakeholder organizations including professional societies and government agencies. Recommendations were finalized and voted on at the consensus meeting. The final, approved recommendations standardize biologically relevant histopathologic terminology for HPV-associated squamous intraepithelial lesions and superficially invasive squamous carcinomas across all lower anogenital tract sites and detail the appropriate use of specific biomarkers to clarify histologic interpretations and enhance diagnostic accuracy. A plan for disseminating and monitoring recommendation implementation in the practicing community was also developed. The implemented recommendations will facilitate communication between pathologists and their clinical colleagues and improve accuracy of histologic diagnosis with the ultimate goal of providing optimal patient care.

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Section: Site-specific Recommendationsmentioning

confidence: 99%

Section: Site-specific Recommendationsmentioning

confidence: 99%

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Darragh

Colgan

Cox

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

643

372

View full text Add to dashboard Cite

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“…5,14,15 Our results showed a strong association between LVSI and disease persistence ( Table 6), implicating that the difficulties and inaccuracies encountered in the histological assessment of this variable in the routine diagnosis do not obscure its true clinical significance. Interestingly, we also found a 0% prevalence of LVSI among lesions less than 1 mm deep, and a greater prevalence (50.9%) observed for cases with 3.1 to 5.0 mm invasion.…”

Section: Discussionmentioning

confidence: 55%

“…Pooling the available data into 1 analysis has also proven to be an extremely difficult task. 5,6 In addition to the highly variable follow-up times, an often unsolved problem has been how to define and separate disease persistence from disease recurrence. Clearly, more work is needed to characterize the lesions and assess the outcome of MIC.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to these basic disease features, however, many clinical reports have suggested that the risk of invasive disease, para-aortic and pelvic lymph node metastases, or death might be influenced by tumor volume, histological grade, invasive growth pattern, lymphovascular space invasion (LVSI), and stromal reaction. 4,5 Despite the controversial views being expressed about the selection criteria, there has been an increasing recent trend to treat patients with MIC with a conservative approach. As a consequence, the risk of (1) disease persistence and (2) invasive and (3) noninvasive cervical recurrences has been introduced as further measures of patient outcome.…”

mentioning

confidence: 99%

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