2015
DOI: 10.1038/ijos.2015.28
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Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss

Abstract: Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors. Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases. Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride (NaF) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that… Show more

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Cited by 28 publications
(28 citation statements)
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“…P. gingivalis ATCC 33277 was grown at 37°C for 24 hours in an anaerobic chamber, with an atmosphere of 85% N 2 , 10% H 2 and 5% CO 2 in brain heart infusion broth supplemented with 5 mg/mL yeast extract, 5 μg/mL hemin and 0.2 μg/mL vitamin K 1, as previously described . LPS from P. gingivalis ATCC 33277 was obtained from P. gingivalis according to the manufacturer’s instructions (iNtRON Biotechnology, Kyungki‐Do, Korea).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…P. gingivalis ATCC 33277 was grown at 37°C for 24 hours in an anaerobic chamber, with an atmosphere of 85% N 2 , 10% H 2 and 5% CO 2 in brain heart infusion broth supplemented with 5 mg/mL yeast extract, 5 μg/mL hemin and 0.2 μg/mL vitamin K 1, as previously described . LPS from P. gingivalis ATCC 33277 was obtained from P. gingivalis according to the manufacturer’s instructions (iNtRON Biotechnology, Kyungki‐Do, Korea).…”
Section: Methodsmentioning
confidence: 99%
“…An established method of experimental periodontitis has been reported . Briefly, 5‐week‐old male C57BL/6 (CLEA Japan, Inc., Tokyo, Japan) and DEC1 KO mice were given sulfamethoxazole (1 mg/mL) and trimethoprim (200 μg/mL) in their drinking water for 4 days to reduce any existing oral microorganisms, followed by a 3 day antibiotic‐free period before starting oral treatment with P. gingivalis .…”
Section: Methodsmentioning
confidence: 99%
“…In addition, bioactive glass including borate is more resistant to Escherichia coli than silica-based glass 17) . Antibacterial effects of fluoride and borate were reported to promote wound healing as a secondary effect 18,19) . Therefore, we speculated that a root canal sealer containing S-PRG fillers might enhance periapical periodontal tissue healing through antibacterial effects by ion release.…”
Section: Introductionmentioning
confidence: 99%
“…17 Fluorine, an indispensable trace element belonging to halogens group, was necessary for human health, such as nervous regulation and dental caries prevention. 20 Titanium surface modified with fluoride could increase the synthesis of osteoprotegerin, and impeded osteoclasts activation and differentiation were followed. 18 Fluorine bounds to a mitogenic stimulus for osteoblasts and possesses the capability to promote osteoblasts proliferation, enhance bone formation.…”
Section: Introductionmentioning
confidence: 99%