Micromorphological Changes in the Organs of Dogs After the Infection of Dirofilaria Repens

Abstract

With the widespread infection of Dirofilaria repens in dogs on the territory of the Russian Federation, the morphological changes in this disease are not well described, and the carcinogenic effect of these helminths on the host has not been established. We have carried out a comprehensive study of morphological changes in the tissues of outbred dogs (the mammary gland of two females and the testes of one male) with subcutaneous dirofilariasis. Excised neoplasms were sent for histological examination, as a result, the females were diagnosed with papillary breast cancer with areas of chondroid differentiation, necrosis, diffuse type of growth, fibrocystic non-proliferative mastopathy. In the male, the histological diagnosis corresponded to chronic orchitis, sclerotic changes were expressed in the epididymis with atrophic and cystic changes in the vas deferens. The uniformity of the micromorphological picture of the neoplastic process in the mammary gland in females may have a certain relationship with the invasion of D. repens due to chronic mechanical traumatization of the host tissues by helminths, as well as their toxic and immune effects. The described impact, in our opinion, was the cause of dystrophy of the male reproductive glands. In general, the study of the relationship between infection with D. repens and the oncological process requires further, more in-depth and private study.