Microneedles and their Applications

Sachdeva, Vishal; Banga, Ajay K.

doi:10.2174/187221111795471445

Cited by 54 publications

(33 citation statements)

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“…In fact, despite the different materials and technologies developed so far for the fabrication of microneedles for transdermal applications, [3][4][5][6][7][8][9][10][11][12][13][14][15][16] only few works deal with needles featuring both density and size values that are comparable to those of the microneedles reported in this work. 24 View Online usually concern arrays of microneedles that feature density at least two orders of magnitude lower and size at least one order of magnitude higher than the ones reported in this work.…”

Section: Insertion Tests In Skin-like Polymersmentioning

confidence: 96%

A minimally invasive microchip for transdermal injection/sampling applications

et al. 2012

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The design, fabrication, and characterization of a minimally invasive silicon microchip for transdermal injection/sampling applications are reported and discussed. The microchip exploits an array of silicon-dioxide hollow microneedles with density of one million needles cm(-2) and lateral size of a few micrometers, protruding from the front-side chip surface for one hundred micrometers, to inject/draw fluids into/from the skin. The microneedles are in connection with independent reservoirs grooved on the back-side of the chip. Insertion experiments of the microchip in skin-like polymers (agarose hydrogels with concentrations of 2% and 4% wt) demonstrate that the microneedles successfully withstand penetration without breaking, despite their high density and small size, according to theoretical predictions. Operation of the microchip with different liquids of biomedical interest (deionized water, NaCl solution, and d-glucose solution) at different differential pressures, in the range 10-100 kPa, highlights that the flow-rate through the microneedles is linearly dependent on the pressure-drop, despite the small section area (about 13 μm(2)) of the microneedle bore, and can be finely controlled from a few ml min(-1) up to tens of ml min(-1). Evaporation (at room temperature) and acceleration (up to 80 g) losses through the microneedles are also investigated to quantify the ability of the chip in storing liquids (drug to be delivered or collected fluid) in the reservoir, and result to be of the order of 70 nl min(-1) and 1300 nl min(-1), respectively, at atmospheric pressure and room temperature.

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Section: Insertion Tests In Skin-like Polymersmentioning

confidence: 96%

A minimally invasive microchip for transdermal injection/sampling applications

et al. 2012

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“…This review has not covered the key parameters like development, fabrication, failure analysis, etc . Sachdeva and Banga [19] reported good comprehensive review on microneedles design, development, safety and regulatory issue, therapeutic applications and limitations of microneedles for commercialization. However, this review has not described the fabrication techniques of microneedles, failure of microneedles due to various applied forces, structural and fluidic analysis and integration issues of microneedles with micropumps.…”

Section: Introductionmentioning

confidence: 99%

Micro Electromechanical Systems (MEMS) Based Microfluidic Devices for Biomedical Applications

Ashraf

Tayyaba

Afzulpurkar

2011

IJMS

220

115

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Micro Electromechanical Systems (MEMS) based microfluidic devices have gained popularity in biomedicine field over the last few years. In this paper, a comprehensive overview of microfluidic devices such as micropumps and microneedles has been presented for biomedical applications. The aim of this paper is to present the major features and issues related to micropumps and microneedles, e.g., working principles, actuation methods, fabrication techniques, construction, performance parameters, failure analysis, testing, safety issues, applications, commercialization issues and future prospects. Based on the actuation mechanisms, the micropumps are classified into two main types, i.e., mechanical and non-mechanical micropumps. Microneedles can be categorized according to their structure, fabrication process, material, overall shape, tip shape, size, array density and application. The presented literature review on micropumps and microneedles will provide comprehensive information for researchers working on design and development of microfluidic devices for biomedical applications.

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“…The use of MNs as a method for the transdermal delivery of drugs has become a more appealing technique as it overcomes many disadvantages, such as discomfort and pain that can be caused by hypodermic needles or the non-bioavailability that oral dosage forms provide. Therefore, it is important to look at patents that have been filed within the last decade to correlate the trends of MNs (Rizwan et al, 2009;Sachdeva & Banga, 2011;Singh et al, 2011). Table 4 lists a summary of patents that have been taken out on materials to fabricate MNs.…”

Section: Mns Patentsmentioning

confidence: 99%

Microneedles for drug delivery: trends and progress

2014

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In recent years, there has been a surge in the research and development of microneedles (MNs), a transdermal delivery system that combines the technology of transdermal patches and hypodermic needles. The needles are in the hundreds of micron length range and therefore allow relatively little or no pain. For example, biodegradable MNs have been researched in the literature and have several advantages compared with solid or hollow MNs, as they produce non-sharp waste and can be designed to allow rapid or slow release of drugs. However, they also pose a disadvantage as successful insertion into the stratum corneum layer of the skin relies on sufficient mechanical strength of the biodegradable material. This review looks at the various technologies developed in MN research and shows the rapidly growing numbers of research papers and patent publications since the first invention of MNs (using time series statistical analysis). This provides the research and industry communities a valuable synopsis of the trends and progress being made in this field.

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Microneedles and their Applications

Cited by 54 publications

References 0 publications

A minimally invasive microchip for transdermal injection/sampling applications

A minimally invasive microchip for transdermal injection/sampling applications

Micro Electromechanical Systems (MEMS) Based Microfluidic Devices for Biomedical Applications

Microneedles for drug delivery: trends and progress

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