Microneedling combined with botulinum toxin-A versus microneedling combined with platelet-rich plasma in treatment of atrophic acne scars: a comparative split face study

Abstract

Background Atrophic post-acne scarring constitutes a troublesome cosmetic concern for both patients and dermatologists. Old and new therapies as well as combinations are being introduced to achieve a satisfactory response. Microneedling has been used either alone or under different combinations for its treatment. The aim was to compare its combination with topical platelet-rich plasma versus its combination with topical Botulinum Toxin-A. Methods 30 subjects with different types and grades of atrophic post-acne scars completed the study. Right side of the face was treated with microneedling and platelet-rich plasma while the left side was treated microneedling and Botox. Response was assessed using two different scales. Patient satisfaction and pain were also assessed. Results Regarding response to therapy and according to the quartile grading scale, there was no statistically significant difference between the two sides where (23.4% & 13.3%) of the right and left sides, respectively, had an excellent response. Regarding the difference in the qualitative global scarring grading system before and after treatment, there was a highly statistically significant improvement on both sides with higher improvement on the right side than left side but in a non-statistically significant way. Conclusions Both combinations present efficacious options for treating acne scars with comparable efficacy. Trial registration Registered and approved prospectively by the ethical review board of the faculty of medicine, Zagazig University.

Evaluation and comparison of the efficacy and safety of the combination of topical phenytoin and microneedling with microneedling alone in the treatment of atrophic acne scars: A controlled blinded randomized clinical trial

“… 19 , 20 , 21 , 22 , 23 In a study by Waleed Albalat et al which compared effectiveness of microneedling combined with botulinum toxin‐A versus microneedling combined with platelet‐rich plasma in treatment of atrophic acne scars, the results showed that there was no significant difference between two methods in the treatment of atrophic acne scars and Both combinations are effective options for treating acne scars. 24 Another study by Sahar A. Ismail which compared the microneedling alone or platelet rich plasma alone or combined both therapeutic in the treatment of atrophic acne scars, their results showed that the skin microneedling, PRP and combined microneedling with PRP are effective therapeutic approaches in atrophic post‐acne scars treatment. However, combined microneedling with PRP had better outcomes in all subgroups of atrophic acne scars.…”

“…There were several studies that compare efficacy of different treatment methods in the atrophic acne scars 19–23 . In a study by Waleed Albalat et al which compared effectiveness of microneedling combined with botulinum toxin‐A versus microneedling combined with platelet‐rich plasma in treatment of atrophic acne scars, the results showed that there was no significant difference between two methods in the treatment of atrophic acne scars and Both combinations are effective options for treating acne scars 24 . Another study by Sahar A. Ismail which compared the microneedling alone or platelet rich plasma alone or combined both therapeutic in the treatment of atrophic acne scars, their results showed that the skin microneedling, PRP and combined microneedling with PRP are effective therapeutic approaches in atrophic post‐acne scars treatment.…”