Micronization Techniques for Solubility Enhancement of Aceclofenac as a potential Solubility Enhancement Approach

Abstract

Aceclofenac is a BCS class II poorly aqueous soluble drug that has significant oral bioavailability limitations after intake. Numerous solubility enhancement techniques are available for the solubility enhancement, out of various techniques Micronization is simple, quick and an effective technique for solubility enhancement. The aim of present research work is use Micronization Technique for solubility enhancement. Micronization technique increases the solubility of Pure Aceclofenac through increasing particle surface area. Aceclofenac material is micronized by Air Jet mill to produces materials of below 25µm size ranges. This micronized Aceclofenac material further characterized for physical property and aqueous solubility determinations. Micronization technique reduces crystllanity of pure Aceclofenac material by increasing their surface area and exhibited increase in dissolution of micronized Aceclofenac as compared to Pure Aceclofenac. Various characterization techniques (DSC, XRD & SEM) also reveal that Aceclofenac crystallinity is significantly minimized due to either conversion of crystalline compound in to amorphous form or reduction of particle size to its molecular level.