Micronodular thymoma with lymphoid stroma: a clinicopathological study of five cases

Hulme, Katherine; Mahar, Annabelle; Cao, Christopher; McCaughan, Brian C.; Cooper, Wendy A.

doi:10.1016/j.pathol.2021.01.016

Cited by 2 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many of the latest pathological studies (Oramas et al ( 7 ) [25 cases, 100%]; Hulme et al. ( 8 ) [4 cases, 80%]; Liu et al. ( 9 ) [4 cases, 100%]) believe that MTWLS has a high rate of cystic changes, which is consistent with our study.…”

Section: Discussionsupporting

confidence: 92%

Micronodular thymoma with lymphoid stroma: Contrast-enhanced CT features with histopathological correlation in 10 patients

et al. 2022

View full text Add to dashboard Cite

ObjectivesThis study aimed to evaluate and summarize the contrast-enhanced computed tomography (CECT) imaging features of micronodular thymoma with lymphoid stroma (MTWLS) based on all MTWLS patients at our institution and was the first imaging study of MTWLS worldwide.MethodsThis retrospective study included 10 MTWLS patients who underwent CECT between April 2012 and November 2021. We collected and analyzed the CECT imaging features, including the location, size, shape, tumor density, classification, and CT value of the solid component. Descriptive statistical analysis was performed using the SPSS software (version 26.0; IBM).ResultsTen patients (five males [50%], five females [50%]; median age, 61.4 years; range, 54-72 years) underwent CECT. Of the 10 cases, one case was purely cystic, seven cases were cystic-solid, and two cases were purely solid. Six cases were round/oval in shape, and four cases were irregularly shaped. Excluding a purely cystic tumor with an unmeasurable degree of enhancement, two cases showed moderate enhancement, and seven cases showed significant enhancement. Among the solid or cystic-solid cases, the mean CT value of the measurable solid component on the enhanced scan was 93.9 HU. Nine masses were located adjacent to the mediastinal pleura, pericardium, or large vessels. Additionally, there were no malignant tumor signs in any patient, including penetration of the mediastinal pleura or involvement of the pericardium, pleural effusion, elevation of the diaphragm, or direct vascular invasion.ConclusionMTWLS demonstrates certain features on CECT, such as a high rate of cystic change, significant solid component enhancement, and no malignant, invasive imaging features. These CECT features are helpful for diagnosing MTWLS.

show abstract

Section: Discussionsupporting

confidence: 92%

Micronodular thymoma with lymphoid stroma: Contrast-enhanced CT features with histopathological correlation in 10 patients

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Micronodular thymoma with lymphoid stroma was originally described by Suster and Moran as an unusual variant of spindle cell thymoma, and since the publication, there have been 117 cases reported in English literature 1–19. The tumour is characterised by distinct morphology; multiple small discrete nodules of bland appearing spindle to oval epithelial cells in an epithelial cell free lymphoid rich stroma.…”

Section: Introductionmentioning

confidence: 99%

GTF2Imutation in micronodular thymoma with lymphoid stroma

et al. 2022

View full text Add to dashboard Cite

AimsMicronodular thymoma with lymphoid stroma is a rare subtype of thymoma with characteristic clinical and pathological features. Some of the features, such as indolent nature, principally spindle morphology and no significant association to myasthenia gravis, are shared with type A and AB thymoma, which is closely linked toGTF2Imutation. However, not much is known regarding the molecular genetics of this thymoma subtype. In this study, theGTF2Imutation status was investigated in 16 cases of micronodular thymoma.Methods16 micronodular thymomas were retrieved and the GTF2I mutation was tested by Sanger sequencing. The clinicopathological findings were documented.ResultsGTF2I c.1271T>A p.(Leu424His) mutation within exon 15 was detected in 14 out of 16 tumours (87.5%). Two patients died of other causes while all others remained alive with no evidence of recurrence during the follow-up period ranging from 19 to 188 months (median: 100 months).ConclusionsGTF2I mutation status and presence of spindle cell morphology may indicate that type A and AB thymoma, and micronodular thymoma represent a group biologically distinct from type B thymomas, which generally lack this mutation.

show abstract

Micronodular thymoma with lymphoid stroma: a clinicopathological study of five cases

Cited by 2 publications

References 9 publications

Micronodular thymoma with lymphoid stroma: Contrast-enhanced CT features with histopathological correlation in 10 patients

Micronodular thymoma with lymphoid stroma: Contrast-enhanced CT features with histopathological correlation in 10 patients

GTF2Imutation in micronodular thymoma with lymphoid stroma

Contact Info

Product

Resources

About