Micronuclei induced by airborne particulate matter from Mexico City

Roubicek, Deborah A.; Gutiérrez-Castillo, María Eugenia; Sordo, Monserrat; Cebrián-García, Mariano E.; Ostrosky‐Wegman, Patricia

doi:10.1016/j.mrgentox.2007.04.001

Cited by 31 publications

(16 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It would be significant to be able to explore other biomarkers that show effects in early stages of pregnancy or biomarkers that indicate longterm effects with impact on the childhood of the individuals exposed in utero in MCMA, such as those involved in neonatal epigenetic reprogramming (Perera et al, 2009a;Tang et al, 2012;Herbstman et al, 2013;Lee et al, 2017). Additionally, neonates born in other sites of MCMA could show different molecular effects due to the differential composition and distribution of PM and ozone (Gutierrez-Castillo et al, 2006;Roubicek et al, 2007;SEDEMA, 2008SEDEMA, , 2010.…”

Section: Discussionmentioning

confidence: 99%

“…OCs include polycyclic aromatic hydrocarbons (PAHs), which have an important epidemiological significance because these compounds are mutagenic and carcinogenic agents (Poirier, ; EPA, ; IARC, ). The in vitro evidence shows that the PM 10 from the MCMA induces DNA damage in A549 cells, (De Vizcaya‐Ruiz et al, ; Sanchez‐Perez et al, ), micronuclei in leucocytes (Roubicek et al, ), and apoptosis in human and mouse cell lines (Alfaro‐Moreno et al, ). Additionally, it has also been shown that PAHs associated with PM 10 from the MCMA can generate DNA adducts in blood leucocytes and A549 cells (Salcido‐Neyoy et al, ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prenatal exposure to particulate matter and ozone: Bulky DNA adducts, plasma isoprostanes, allele risk variants, and neonate susceptibility in the Mexico City Metropolitan Area

Maciel‐Ruiz

López‐Rivera

Robles‐Morales

et al. 2019

Environ and Mol Mutagen

View full text Add to dashboard Cite

Mexico City's Metropolitan Area (MCMA) includes Mexico City and 60 municipalities of the neighbor states. Inhabitants are exposed to emissions from over five million vehicles and stationary sources of air pollutants such as particulate matter (PM) and ozone. MCMA PM contains elemental carbon and organic carbon (OC). OCs include polycyclic aromatic hydrocarbons (PAHs), many of which induce mutagenic and carcinogenic DNA adducts. Gestational exposure to air pollution has been associated with increased risk of intrauterine growth restriction, preterm birth or low birth weight risk, and PAH‐DNA adducts. These effects also depend on the presence of risk alleles. We investigated the presence of bulky PAH‐DNA adducts, plasma 8‐iso‐PGF2α (8‐iso‐prostaglandin F2α) and risk allele variants in neonates cord blood and their non‐smoking mothers' leucocytes from families that were living in a highly polluted area during 2014–2015. The presence of adducts was significantly associated with both PM2.5 and PM10 levels, mainly during the last trimester of gestation in both neonates and mothers, while the last month of pregnancy was significant for the association between ozone levels and maternal plasma 8‐iso‐PGF2α. Fetal CYP1B1*3 risk allele was associated with increased adduct levels in neonates while the presence of the maternal allele significantly reduced the levels of fetal adducts. Maternal NQO1*2 was associated with lower maternal levels of adducts. Our findings suggest the need to reduce actual PM limits in MCMA. We did not observe a clear association between PM and/or adduct levels and neonate weight, length, body mass index, Apgar or Capurro score. Environ. Mol. Mutagen. 60:428–442, 2019. © 2019 Wiley Periodicals, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to particulate matter and ozone: Bulky DNA adducts, plasma isoprostanes, allele risk variants, and neonate susceptibility in the Mexico City Metropolitan Area

Maciel‐Ruiz

López‐Rivera

Robles‐Morales

et al. 2019

Environ and Mol Mutagen

View full text Add to dashboard Cite

show abstract

“…The activation of the Nfr2 pathway could be a crucial regulator of the oxidative DNA damage that is induced by air pollutants (Rojas et al 2000;Hayes and McMahon 2000;Lee and Shur 2005;Jeong et al 2006;Tovalin et al 2006;Braüner et al 2007;Roubicek et al 2007;Singh et al 2007). Thus, the aim of this paper is to review the role of the Nrf2 pathway against exposure to air pollutants.…”

Section: Nrf2mentioning

confidence: 99%

Effects of atmospheric pollutants on the Nrf2 survival pathway

Rubio

Valverde

Rojas

2009

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…The basin of Mexico is not a flat surface with standard meteorological and topographical conditions; it is neither homogenous in its social, economic, commercial, and transport networks. On the contrary, the city is a mixture of micro-environments entangled within an intricate collection of geomorphological features in which conditions can change from one place to another, including the induced biological effects caused by a different composition of the particulate matter [63,64].…”

Section: Discussionmentioning

confidence: 99%

Distribution of PM2.5 Air Pollution in Mexico City: Spatial Analysis with Land-Use Regression Model

2019

View full text Add to dashboard Cite

Featured Application: Modeling the spatial distribution of PM 2.5 with personal monitors and an LUR approach may be useful for local authorities to make accountable public policy decisions.Abstract: In this study, the spatial distribution of PM 2.5 air pollution in Mexico City from 37 personal exposures was modeled. Meteorological, demographic, geographic, and social data were also included. Geographic information systems (GIS), spatial analysis, and Land-Use Regression (LUR) were used to generate the final predictive model and the spatial distribution map which revealed two areas with very high concentrations (up to 109.3 µg/m 3 ) and two more with lower concentrations (between 72 to 86.5 µg/m 3 ) (p < 0.05). These results illustrate an overview trend of PM 2.5 in relation to human activity during the studied periods in Mexico City and show a general approach to understanding the spatial variability of PM 2.5 .

show abstract

Micronuclei induced by airborne particulate matter from Mexico City

Cited by 31 publications

References 35 publications

Prenatal exposure to particulate matter and ozone: Bulky DNA adducts, plasma isoprostanes, allele risk variants, and neonate susceptibility in the Mexico City Metropolitan Area

Prenatal exposure to particulate matter and ozone: Bulky DNA adducts, plasma isoprostanes, allele risk variants, and neonate susceptibility in the Mexico City Metropolitan Area

Effects of atmospheric pollutants on the Nrf2 survival pathway

Distribution of PM2.5 Air Pollution in Mexico City: Spatial Analysis with Land-Use Regression Model

Contact Info

Product

Resources

About