Micronutrients and Dengue

Ahmed, S. Ashraf; Finkelstein, Julia L.; Stewart, Anna; Kenneth, John; Polhemus, Mark E.; Endy, Timothy P.; Cárdenas, Washington B.; Mehta, Saurabh

doi:10.4269/ajtmh.14-0142

Cited by 34 publications

(31 citation statements)

References 65 publications

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“…Vitamin E has well known antioxidant properties, through its ability to donate a hydrogen group from its free hydroxyl group to the free radical, with the generation of a stable free radical form of vitamin E. However, a number of non-antioxidant activities of vitamin E have been demonstrated [ 21 ]. α-Tocopherol has been reported to have some effects in dengue patients [ 22 ] and has proposed benefits for influenza virus A infection [ 23 ], as well as possible activity against hepatitis B [ 24 ] and C [ 25 ]. In this study, α-tocopherol showed proviral effects, particularly in HEK293T/17 cells (Fig.…”

Section: Main Textmentioning

confidence: 99%

Screening of melatonin, α-tocopherol, folic acid, acetyl-l-carnitine and resveratrol for anti-dengue 2 virus activity

et al. 2018

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ObjectiveInfections with the mosquito transmitted dengue virus (DENV) are a significant public health burden in many parts of the world. Despite the introduction of a commercial vaccine in some parts of the world, the majority of the populations at risk of infection remain unprotected against this disease, and there is currently no treatment for DENV infection. Natural compounds offer the prospect of cheap and sustainable therapeutics to reduce the disease burden during infection, and thus potentially alleviate the risk of more severe disease. This study evaluated the potential anti-DENV 2 activity of five natural compounds namely melatonin, α-tocopherol, folic acid, acetyl-l-carnitine and resveratrol in two different cell lines.ResultsScreening of the compounds showed that one compound (acetyl-l-carnitine) showed no effect on DENV infection, three compounds (melatonin, α-tocopherol and folic acid) slightly increased levels of infection, while the 5th compound, resveratrol, showed some limited anti-DENV activity, with resveratrol reducing virus output with an EC50 of less than 25 μM. These results suggest that some commonly taken natural compounds may have beneficial effects on DENV infection, but that others may potentially add to the disease burden.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3417-3) contains supplementary material, which is available to authorized users.

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Section: Main Textmentioning

confidence: 99%

Screening of melatonin, α-tocopherol, folic acid, acetyl-l-carnitine and resveratrol for anti-dengue 2 virus activity

et al. 2018

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“…Emerging evidence supports a role of micronutrients in neglected tropical diseases [ 20 ]. In a 2012 report on neglected zoonoses, WHO cited nutritional status as an underappreciated, underlying cause of death in zoonotic infections [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Micronutrients and Leptospirosis: A Review of the Current Evidence

et al. 2016

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BackgroundLeptospirosis is one of the most widespread zoonoses and represents a major threat to human health. Due to the high burden of disease, limitations in diagnostics, and limited coverage and availability of effective human and veterinary vaccines, leptospirosis remains an important neglected zoonotic disease. Improved surveillance and identification of modifiable risk factors for leptospirosis are urgently needed to inform preventive interventions and reduce the risk and severity of Leptospira infection.Methodology/Principal FindingsThis review was conducted to examine the evidence that links micronutrient status and Leptospira infection. A total of 56 studies were included in this review: 28 in vitro, 17 animal, and 11 observational human studies. Findings indicated that Leptospira infection is associated with higher iron and calcium concentrations and hypomagnesemia.Conclusions/SignificanceFew prospective studies and no randomized trials have been conducted to date to examine the potential role of micronutrients in Leptospira infection. The limited literature in this area constrains our ability to make specific recommendations; however, the roles of iron, calcium, and magnesium in leptospirosis represent important areas for future research. The role of micronutrients in leptospirosis risk and severity needs to be elucidated in larger prospective human studies to inform public health interventions.

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“…In the present study, the serum levels of Fe, Zn and Mg were found to be unaltered in NS1 positive cases with or without IgM positivity, in cases with IgM positivity and in OFI group compared to healthy blood donors from both local rural and urban population. There is paucity of data on systemic analysis of serum micronutrient levels in DF cases, especially in relation to clinical severity except few studies on ferritin and Zn [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Trace Elements, Proinflammatory Cytokines and Nitric Oxide in NS1 Positive Cases in Acute Dengue Virus Infections

Verghese¹,

Singh²,

Chattopadhya³

2018

Clin Infect Immun

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Background: Dengue virus (DENV) infection is characterized by severe vascular complications viz. dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in a perceptible population justifying the need for an early marker that could reliably predict such adverse outcomes. A nonstructural protein antigen of DENV termed NS1 antigen that is detectable during acute stage of DENV infection was evaluated to find out its association with alteration of some trace element levels viz. zinc (Zn), selenium (Se), iron (Fe), copper (Cu) and magnesium (Mg), levels of nitrite (the stable product of NO), as well as levels of interferon gamma (IFN-γ), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-α) in acute stage of DENV infection to find out if any alteration of these parameters associated with NS1 positivity could strengthen its predictive value for development of pathogenic consequences following acute DENV infection. Methods: Estimation of concentrations of trace elements by flame atomic absorption spectrometry (FAAS) method, while the levels of nitrite and citrulline by Griess reaction and cytokine estimation was done by enzyme-linked immunosorbent assay (ELISA) method. Results: There was significant depression of Cu levels in cases positive for NS1 antigen alone (n = 50) or in combination with IgM positivity (n = 15) compared to cases with IgM positivity alone (n = 50), other febrile illness (OFI) group (n = 50) and both rural and urban healthy controls (n = 50 each). Serum level of Se was increased in all the serological subgroups of acute DENV cases, in the OFI group as well as in healthy rural controls compared to urban controls. There was significant depression in nitrite level in NS1 positive cases regardless of associated IgM positivity. The reduced serum nitrite levels in NS1 positive cases, with or without associated IgM positivity, correlated positively with decrease in serum Cu level and negatively with increase in TNF-α level in the corresponding subgroups. Conclusions: The present study revealed altered status of some markers in serum associated with NS1 positivity that may strengthen the validity of NS1 positivity as a predictive marker for development of complications thus help in timely management of DENV infection.

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Micronutrients and Dengue

Cited by 34 publications

References 65 publications

Screening of melatonin, α-tocopherol, folic acid, acetyl-l-carnitine and resveratrol for anti-dengue 2 virus activity

Screening of melatonin, α-tocopherol, folic acid, acetyl-l-carnitine and resveratrol for anti-dengue 2 virus activity

Micronutrients and Leptospirosis: A Review of the Current Evidence

Serum Levels of Trace Elements, Proinflammatory Cytokines and Nitric Oxide in NS1 Positive Cases in Acute Dengue Virus Infections

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