Micropapillary Variant of Transitional Cell Carcinoma of the Urinary Bladder

Ylagan, Lourdes; Humphrey, Peter A.

doi:10.1159/000327871

Cited by 44 publications

(16 citation statements)

References 5 publications

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“…Ylagan and Humphrey reported that they could diagnose a micropapillary variant of TCC by urine cytology. 6 The same categories as MPC have appeared in other types of cancer, such as uterine cancer, 7 breast cancer 8 and ureteral cancer. 9 If MPC is observed in specimens, the prognosis of the patient would be poor.…”

Section: Discussionmentioning

confidence: 82%

Micropapillary variant of transitional cell carcinoma of the bladder

Sugino¹,

Negoro²,

Iwamura³

et al. 2004

Int J of Urology

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A 77-year-old man visited the Kobe City General Hospital complaining of macroscopic hematuria. A computed tomography scan found a bladder tumor with left iliac and para-aortic lymph node metastasis. Two courses of cisplatin, cyclophosphamide and doxorubicin chemotherapy resulted in a minimal response. Radical cystectomy and a retroperitoneal lymph node dissection with bilateral ureterocutaneostomy reconstruction were then performed. A pathological examination revealed a micropapillary variant of transitional cell carcinoma (Grade 3, pT1pN2M1). The patient died of pelvic recurrence 7 months after the initiation of chemotherapy. Peritonitis carcinomatosa and lung metastases were observed at autopsy.

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Section: Discussionmentioning

confidence: 82%

Micropapillary variant of transitional cell carcinoma of the bladder

Sugino¹,

Negoro²,

Iwamura³

et al. 2004

Int J of Urology

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“…FNA is a relatively easy biopsy method with a number of documented cases of breast MPC diagnosed using this approach (10,13,14). However, few cases of MPC in the urinary bladder have been reported, possibly due to the inapplicability of FNA and the availability of urine as the only cytological sample (15,16). Although an increased number of studies examining the role of cytological examination in the lung have been conducted compared with those in the urinary bladder (17), to the best of our knowledge, no cases of primary MPC in the parotid gland or MPC in the lungs presenting with pericardial findings have been previously reported.…”

Section: Discussionmentioning

confidence: 99%

Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases

Huq¹,

Canberk

Öznur

et al. 2014

Oncology Letters

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Micropapillary carcinoma (MPC) is a rare aggressive tumor, which generally accompanies the primary carcinoma of the organ of its origin, while the pure form is extremely uncommon. Angiolymphatic involvement is widespread and a considerable proportion of the cases present with metastases. The current study presents eight pure MPC cases arising from the breast (n=3), urinary bladder (n=3), parotid gland (n=1) and lung (n=1, presenting with pericardial effusion), with the cytological findings. The eight patients included three female and five male cases aged between 48 and 74 years. The most common cytological findings were three-dimensional aggregates, cell clusters with angulated or scalloped borders, single cells with a columnar configuration and eccentric nuclei, and high-grade nuclear features. Histopathological sections showed accompanying in situ ductal carcinoma in the cases of MPC arising in the parotid gland and breast (n=3), and one case in the bladder exhibited only in situ MPC. The average follow-up period was 20 months (range, 6–54 months) and, during this period, three patients succumbed to the disease. At present, four patients are alive with disease and one patient is alive and disease-free. In conclusion, cytology is an important tool for the diagnosis and management of MPC.

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“…In this sense, the cytology of the aggressive variant of urothelial MPC is peculiar, having numerous epithelial clusters with variable participation of elongated pseudopapillary fragments, morules and acinar structures with high-grade nuclear atypia. The cytology of this MPC variant is basically a mixture of a high-grade urothelial carcinoma with partial architectural features of a low-grade neoplasm [9]. Previous cytologic reports include two series and a few case reports, some of which involve FNA [9,10,11,12,13,14,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…The cytology of this MPC variant is basically a mixture of a high-grade urothelial carcinoma with partial architectural features of a low-grade neoplasm [9]. Previous cytologic reports include two series and a few case reports, some of which involve FNA [9,10,11,12,13,14,15,16]. The present study is generally in agreement with these previous papers, which report a predominance of smears, showing atypical cells distributed mainly as tight clusters.…”

Section: Discussionmentioning

confidence: 99%

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Micropapillary Carcinoma of the Urinary Tract: A Cytologic Study of Urine and Fine-Needle Aspirate Samples

et al. 2014

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Objective: Micropapillary carcinoma (MPC) is an aggressive variant of urothelial carcinoma that needs early and specific recognition. In order to determine whether this tumor variant can be recognized with cytology, we evaluated a large cytohistological series. Study Design: It was a retrospective cytohistological correlation study including 20 patients with MPC. Only those cases in which the tumor exhibited >50% of micropapillary growth were selected. Twenty exfoliative urine specimens and four needle aspirates from lymph node metastases were reviewed. Results: On histology, 14 cases were infiltrative, while 6 were exclusively superficial. Cytology was characterized by numerous small, cohesive groups and single neoplastic cells. Pseudopapillae were present in 17 cases and in 9 they were a relevant finding. Morules were present in 15 cases. Isolated microacini were seen in 14 cases. Infiltrative tumors showed more neoplastic groups. Cellular atypia was prominent in 17 cases. In 15 cases, a cytologic diagnosis of urothelial carcinoma was made. One case was diagnosed as adenocarcinoma. The remaining 4 cases were considered suspicious of malignancy. Conclusions: The peculiar morphology of MPC of the urinary tract is partially reflected on cytology, allowing in some cases a specific recognition. This is important since the aggressive behavior of this neoplasm needs rapid management and treatment.

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Micropapillary Variant of Transitional Cell Carcinoma of the Urinary Bladder

Cited by 44 publications

References 5 publications

Micropapillary variant of transitional cell carcinoma of the bladder

Micropapillary variant of transitional cell carcinoma of the bladder

Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases

Micropapillary Carcinoma of the Urinary Tract: A Cytologic Study of Urine and Fine-Needle Aspirate Samples

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