Microparticles Formulation as a Targeting Drug Delivery System

Abdellatif, Ahmed A. H.

doi:10.15406/jnmr.2017.06.00151

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…Prepared ceftriaxone loaded chitosan microparticles successfully decrease the MIC [18][19] of the bacteria and hence have the potential to decrease associated toxicity.…”

Section: In-vitro Release Kineticsmentioning

confidence: 99%

Formulation Evaluation and Optimization of Chitosan Coated Ceftriaxone Loaded Microparticles

Jain

Choudhary

Islam

2020

Int. J. Pharm. Sci. Drug Res.

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Ceftriaxone, a third generation cephalosporin antibiotic is an important antibiotic used in the treatment of invasive infections caused by the certain bacteria such as the penicillin-resistant microorganisms like Staphyloccocus aureus, strains of S. pneumonia, S. aureus and Enterobacteriaceae , particularly among E. coli. There is increasing antimicrobial resistance of Ceftriaxone in particular against these strains of bacteria. This study has been conducted to formulate, evaluate and optimize chitosan coated ceftriaxone loaded microparticles with better efficacy and also observes the MIC against strains of bacteria. Emulsion crosslinking method was used for the formulation of microparticles of ceftriaxone by using chitosan as a polymer and glutraldehyde as a cross linking agent which is optimized by using Box-Behnken Design. Three independent variables were taken; effect of drug and the polymer ratio, effect of the stirring speed and effect of crosslinking agent and dependent variables were microparticles entrapment efficiency and the In vitro drug release. Following optimization of the formulations, physical characterization as well as entrapment efficiency and ultimately in-vitro evaluation was performed. Physical characterization include optical microscopy, SEM and DLS to check there physical properties. The method used for the formulation of microparticle had the optimum entrapment efficiency of 61.7% which was increase with the increase in the addition of the more amount of chitosan and glutraldehyde and method also achieved the good in vitro release. MIC studies of microparticles were done against Klebsiella pneumonia, Staphylococcus aureus, Streptococcus mutans, Escherichia coli and it was found that the formulations showed decrease in MIC.

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“…Prepared ceftriaxone loaded chitosan microparticles successfully decrease the MIC [18][19] of the bacteria and hence have the potential to decrease associated toxicity.…”

Section: In-vitro Release Kineticsmentioning

confidence: 99%

Formulation Evaluation and Optimization of Chitosan Coated Ceftriaxone Loaded Microparticles

Jain

Choudhary

Islam

2020

Int. J. Pharm. Sci. Drug Res.

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“…It was reported that if the drug dissolves in the matrix in which dispersed, both matrix and partition control is possible. If drug has low solubility in the elution medium, partition control dominates and the release is zero order [38][39][40], that is; Q = K D Cs t / h…”

Section: The Embedded Matrix Principlementioning

confidence: 99%

Design of Sustained Action Dosage Forms; Mini-Review

Abdellatif¹

2018

Pharm Anal Acta

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Greatest idealized per-oral sustained action products have been formulated in the form of oral dosage forms such as capsules or tablets. The characteristic trouble of preparing sustained action liquids has controlled the availability of such dosage forms. Encapsulated long-acting dosage forms have two particular benefits over capsules and tablet designs. Firstly, the inability to be disintegrated which may persist in the stomach for long periods of time, extremely suspending in the stomach and retard the absorption of maintenance dose. Secondly, the disintegration of the capsule shell in the gastric fluid releases particles that pass across the pyloric valve. Also, the release of drug by a meaningful fraction of the granules is highly possible. If a tablet fails to release drug, the entire maintenance dose is lost. This review discusses the different methods for enhancing the sustained drug action. cancer cells, such as the SSTRs, the folate receptor, and transferrin receptors. Moreover, nanoparticles coated cell-penetrating peptides and protein-transduction domains, such as oligoarginine and TAT facilitated the uptake of these nanoparticles which cannot successfully enter cancer cells [8]. This review discusses the different methods for enhancing the sustained drug action, the barrier principle, model based on diffusion, and model based on dissolution. Moreover, the review discusses the principle release from the matrix.

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Multichamber PLGA Microparticles with Enhanced Monodispersity and Encapsulation Efficiency Fabricated by a Batch‐Microfluidic Hybrid Approach

Choi,

Kang,

Choi

et al. 2023

Advanced NanoBiomed Research

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Microparticles with multiple internal chambers hold great promise as drug delivery systems due to their ability to sustain the release of drugs with short half‐lives. However, conventional batch methods used for their fabrication have limitations in terms of encapsulation efficiency and particle size distributions, while microfluidic methods suffer from low production efficiency. Herein, a batch‐microfluidic hybrid method is presented for fabricating poly(DL‐lactic‐co‐glycolic acid) (PLGA) polymeric microparticles with uniformly distributed, multiple inner microchambers. A scalable batch method is utilized for primary water‐in‐oil (W/O) emulsions, combined with a precise microfluidic approach for generating controlled secondary emulsions. This approach results in highly uniform PLGA microparticles with tunable size and improved encapsulation efficiency. Additionally, the effect of polydopamine‐based surface hydrophilic modification of microfluidic channels on drug encapsulation efficiency is investigated, achieving an efficiency of approximately 85%. The prepared multichamber PLGA microparticles exhibit an extended‐release profile without initial burst release, demonstrating their potential for sustained drug delivery in various biomedical applications.

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Microparticles Formulation as a Targeting Drug Delivery System

Cited by 6 publications

References 33 publications

Formulation Evaluation and Optimization of Chitosan Coated Ceftriaxone Loaded Microparticles

Formulation Evaluation and Optimization of Chitosan Coated Ceftriaxone Loaded Microparticles

Design of Sustained Action Dosage Forms; Mini-Review

Multichamber PLGA Microparticles with Enhanced Monodispersity and Encapsulation Efficiency Fabricated by a Batch‐Microfluidic Hybrid Approach

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