Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758)

Barboza, Luís Gabriel Antão; Vieira, Luís R.; Branco, Vasco; Figueiredo, Neusa; Carvalho, Félix; Carvalho, Cristina; Guilhermino, Lúcia

doi:10.1016/j.aquatox.2017.12.008

Cited by 560 publications

(216 citation statements)

References 68 publications

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“…In line with MPs/NPs activity as carriers or vectors of environmental contaminants, studies using fish cell lines have revealed that, while pristine plastics show no toxicity, those sampled from different islands around the world do [96], and so do those that have been mixed with human pharmaceuticals [97]. MPs/NPs were shown to modulate the toxicities a range of pollutants/toxicants, including phenanthrene [75], mercury [49], cadmium [46][47][48], polychlorinated biphenyls (PCBs) [98], gold ions [99], and the antibiotic roxithromycin [100], in fishes. However, adsorption of toxicants by the plastics could also potentially lower their toxicity, and such is the case for a complex mixture of polycyclic aromatic hydrocarbons (PAHs) [101].…”

Section: Toxicity Of Mps/nps In Fishesmentioning

confidence: 99%

“…For the gut, pathological manifestations of MP/NP toxicity include documented changes in gut biomarkers related to epithelial barrier integrity, inflammation, and oxidative stress [83,86], as well as changes in gut microbiota [82,83,86]. In the case of liver, changes in metabolites, key metabolic enzymes, and oxidative stress-induced enzymes occur [49,74,79,81,85,87]. MPs/NPs could be internalized [88], and then cause detectable biomarker changes in blood cells [47,88,89].…”

Section: Toxicity Of Mps/nps In Fishesmentioning

confidence: 99%

“…MPs/NPs could be internalized [88], and then cause detectable biomarker changes in blood cells [47,88,89]. In rarer cases, MPs/NPs have also been found in fish brain [68,81], and caused changes in brain appearances [35,68] or showed significantly inhibited acetylcholinesterase (AChE) activity [49,81]. NPs taken up by embryos and larvae have been documented to migrate to various tissues throughout development [70].…”

Section: Toxicity Of Mps/nps In Fishesmentioning

confidence: 99%

“…On the other hand, organic pollutants could be adsorbed onto MPs/NPs [37][38][39][40][41] and there is evidence that this could potentially enhance their effective uptake and toxicity [42][43][44][45]. Likewise, MPs/NPs are known to interact with metallic toxicants such as Cadmium [46][47][48], Mercury [49], and other toxic trace elements [50], and could potentially serve as vectors for pollutant transfer to living organisms.…”

Section: Introductionmentioning

confidence: 99%

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Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

552

280

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Fragmented or otherwise miniaturized plastic materials in the form of micro- or nanoplastics have been of nagging environmental concern. Perturbation of organismal physiology and behavior by micro- and nanoplastics have been widely documented for marine invertebrates. Some of these effects are also manifested by larger marine vertebrates such as fishes. More recently, possible effects of micro- and nanoplastics on mammalian gut microbiota as well as host cellular and metabolic toxicity have been reported in mouse models. Human exposure to micro- and nanoplastics occurs largely through ingestion, as these are found in food or derived from food packaging, but also in a less well-defined manner though inhalation. The pathophysiological consequences of acute and chronic micro- and nanoplastics exposure in the mammalian system, particularly humans, are yet unclear. In this review, we focus on the recent findings related to the potential toxicity and detrimental effects of micro- and nanoplastics as demonstrated in mouse models as well as human cell lines. The prevailing data suggest that micro- and nanoplastics accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences. There is a need for cellular and systemic toxicity due to micro- and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.

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Section: Toxicity Of Mps/nps In Fishesmentioning

confidence: 99%

Section: Toxicity Of Mps/nps In Fishesmentioning

confidence: 99%

Section: Toxicity Of Mps/nps In Fishesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

552

280

View full text Add to dashboard Cite

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“…They then fed these nauplii to zebrafish ( Danio rerio ) and observed trophic transfer of both the microplastics and benzo(a)pyrene. Most such studies examined organic pollutants, but Barboza et al () evaluated interactions between mercury and microplastics, and resulting toxicological implications in fish.…”

Section: Microplastic Uptake and Consequences In Biotamentioning

confidence: 99%

A Global Perspective on Microplastics

Hale¹,

Seeley²,

Guardia³

et al. 2020

JGR Oceans

733

270

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Society has become increasingly reliant on plastics since commercial production began in about 1950. Their versatility, stability, light weight, and low production costs have fueled global demand. Most plastics are initially used and discarded on land. Nonetheless, the amount of microplastics in some oceanic compartments is predicted to double by 2030. To solve this global problem, we must understand plastic composition, physical forms, uses, transport, and fragmentation into microplastics (and nanoplastics). Plastic debris/microplastics arise from land disposal, wastewater treatment, tire wear, paint failure, textile washing, and at-sea losses. Riverine and atmospheric transport, storm water, and disasters facilitate releases. In surface waters plastics/microplastics weather, biofoul, aggregate, and sink, are ingested by organisms and redistributed by currents. Ocean sediments are likely the ultimate destination. Plastics release additives, concentrate environmental contaminants, and serve as substrates for biofilms, including exotic and pathogenic species. Microplastic abundance increases as fragment size decreases, as does the proportion of organisms capable of ingesting them. Particles <20 μm may penetrate cell membranes, exacerbating risks. Exposure can compromise feeding, metabolic processes, reproduction, and behavior. But more investigation is required to draw definitive conclusions. Human ingestion of contaminated seafood and water is a concern. Microplastics indoors present yet uncharacterized risks, magnified by the time we spend inside (>90%) and the abundance of polymeric products therein. Scientific challenges include improving microplastic sampling and characterization approaches, understanding long-term behavior, additive bioavailability, and organismal and ecosystem health risks. Solutions include improving globally based pollution prevention, developing degradable polymers and additives, and reducing consumption/expanding plastic reuse.

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Synthetic Polymers

Skoglund,

Roy,

Cavender

2023

Patty's Toxicology

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The global annual production of plastic is approaching a half‐billion tonnes and two families of synthetic polymers, polyethylene and polypropylene, account for approximately 45% of this production. The most common applications for synthetic polymers are in packaging and consumer/household goods and they are often referred to as single‐use plastics. However, other applications for synthetic polymers include medical/medical device, construction, agriculture, automotive, and industrial uses. Exposure to monomers, polymers, resins, and plastics can occur during the initial polymerization and manufacturing of the resins, the subsequent polymerization and manufacturing of the plastics and finished products, during use of the finished product, and during the product's end‐of‐life stage. This chapter focuses on understanding and mediating the toxicological issues with synthetic polymers in the workplace, including the production of the polymers, the resins, and the finished plastic products. In addition to the toxicology profiles, this chapter discusses production and uses, potential exposures, hazard classification, thermo‐decomposition products, sensitive applications such as food‐contact and medical applications, and exposure guidelines. The environmental impact of these synthetic polymers can be significant, so this chapter also touches on the life cycle of these polymers including recycled and bio‐based feedstocks, carbon emissions, macroplastic and microplastic pollution, degradation in the environment, additives, and end‐of‐life scenarios.

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Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758)

Cited by 560 publications

References 68 publications

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

A Global Perspective on Microplastics

Synthetic Polymers

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