Micropotentiometric sensors

Nam, Hakhyun; Cha, G.S.; Strong, T.D.; Ha, Jeonghan; Sim, Jun Ho; Hower, R.W.; Martin, Steven M.; Brown, Richard B.

doi:10.1109/jproc.2003.813581

Cited by 20 publications

(1 citation statement)

References 51 publications

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“…Moreover, the analytical signal is independent upon the electrode surface area giving amenability to miniaturization. Potentiometric sensors have analytical and economic advantages including ease of fabrication, simple monitoring instrumentation, fast response, application to turbid or colored solutions, high sensitivity, wide linear dynamic ranges, low cost, and possible interfacing with flow injection analysis systems (FIA) [11][12][13]. The potential of these electrodes is dependent on the activity (concentration) of analyte.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Different Modified Potentiometric Sensors for Determination of Moxifloxacin HCl in Dosage Forms

Moamed¹

2015

Pharm Anal Acta

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In situ modified carbon paste, screen-printed and PVC electrodes were fabricated for the determination of moxifloxacin hydrochloride (MOXHC). The electrodes under study revealed linear response over wide concentration range of 1.0×10-6-1.0×10-2 mol L-1 of MOXHC at 25 o C with a monovalent cationic slope. It was found that the slope is 57.2 ± 2.6, 59.2 ± 4.6 and 57.7 ± 2.7 mV decade-1 for IPVC electrodes modified with 7.5 mg NaTPB, PMA and PTA ion pairing agents, respectively, and 58.6 ± 1.7, 60.0 ± 2.0 and 59.0 ± 3.3 mV decade-1 for ISPE modified with 22, 16 and 30 mg NaTPB, RN and PTA ion pairing agents, respectively, but 60 ± 2.3 mV decade-1 for ICPE modified with 10 mg NaTPB. Moreover, the selectivity coefficient of the electrodes was determined by applying both matched potential and separate solution methods. The modified SPE sensor shows high selectivity and sensitivity for determination of MOXHC. The response of the electrodes was found to be pH independent in the range of 2-6 for ISPEs and IPVC electrodes and 3-7 for ICPE electrode. The electrodes under study have short response time. This potentiometric method can be used for determination of MOXHC in pharmaceutical preparation and the results obtained agreed with those obtained with HPLC official method. The proposed potentiometric method was validated according to the IUPAC recommendation.

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Section: Introductionmentioning

confidence: 99%

Comparative Study of Different Modified Potentiometric Sensors for Determination of Moxifloxacin HCl in Dosage Forms

Moamed¹

2015

Pharm Anal Acta

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Electrochemical Measurements

Davey

2005

Handbook of Measuring System Design

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Disposable Miniaturized Screen‐Printed pH and Reference Electrodes for Potentiometric Systems

et al. 2010

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This work describes the development of a miniaturized potentiometric system comprising a miniaturized quasi-reference electrode (QRE) coupled to a solid-state ion-selective electrode (ISE) for the monitoring of pH. We describe the optimization of materials and fabrication processes including screen-printing (SP), electrode treatments (thermal and electrochemical) and the formulation and deposition of an ion-selective membrane (ISM), to obtain a system compliant with biomedical specifications. We developed a potentiometric system composed of an Ag/AgCl QRE and a pH-electrode (ISM deposited on a graphite electrode) that can be used continuously for a period of not less than 7 days in aqueous solutions. Curing the Ag/AgCl pastes during 20 minutes at 120 8C after printing allowed the QREs to display excellent potential stability, as demonstrated by an open-circuit-potential standard deviation of AE 1.2 mV over a period of 7 days (n = 3 samples). Promoting adhesion of the pH membrane over graphite electrodes improved the pH-electrode performance. This was achieved through a combination of thermal treatment and electrochemical activation of the electrodes by cyclic voltammetry (CV). The final device integrated both the QRE and the pH-electrode, and displayed an average pH sensitivity of À60.8 AE 1.7 mV per pH unit, over a pH range of 7.00 to 7.63.

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Micropotentiometric sensors

Cited by 20 publications

References 51 publications

Comparative Study of Different Modified Potentiometric Sensors for Determination of Moxifloxacin HCl in Dosage Forms

Comparative Study of Different Modified Potentiometric Sensors for Determination of Moxifloxacin HCl in Dosage Forms

Electrochemical Measurements

Disposable Miniaturized Screen‐Printed pH and Reference Electrodes for Potentiometric Systems

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