MicroRNA-101 regulates oocyte maturation in vitro via targeting HAS2 in porcine cumulus cells

Luo, Xi; Chen, Xuan; Lv, Yanqiu; Han, Yue; Qu, Xinglin; Zhang, Yuyang; Li, Xin; Yu, Yongsheng; Jin, Yi

doi:10.1016/j.theriogenology.2022.04.025

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…Thus, they function as part of the placental development, neuron, astrocyte, muscle cell development, or bone formation (Fu et al, 2013;Ivey and Srivastava, 2015). Their essential role in embryogenesis, cell development, hemostasis and differentiation has also been reported by several studies conducted on different animal species (He et al, 2022;Khanal et al, 2022;Luo et al, 2022). Given their involvement in numerous physiological processes, it is unsurprising that miRNAs and their aberrant expression have been regarded as potential diagnostic biomarkers in a variety of diseases (Hayes et al, 2014;Tüfekci et al, 2014;Huang, 2017).…”

Section: Introductionmentioning

confidence: 95%

Role of salivary miRNAs in the diagnosis of gastrointestinal disorders: a mini-review of available evidence

Săsăran

Bănescu

2023

Front. Genet.

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MiRNAs are short, non-coding RNA molecules, which are involved in the regulation of gene expression and which play an important role in various biological processes, including inflammation and cell cycle regulation. The possibility of detecting their extracellular expression, within body fluids, represented the main background for their potential use as non-invasive biomarkers of various diseases. Salivary miRNAs particularly gained interest recently due to the facile collection of stimulated/unstimulated saliva and their stability among healthy subjects. Furthermore, miRNAs seem to represent biomarker candidates of gastrointestinal disorders, with miRNA-based therapeutics showing great potential in those conditions. This review aimed to highlight available evidence on the role of salivary miRNAs in different gastrointestinal conditions. Most salivary-based miRNA studies available in the literature that focused on pathologies of the gastrointestinal tract have so far been conducted on pancreatic cancer patients and delivered reliable results. A few studies also showed the diagnostic utility of salivary miRNAs in conditions such as esophagitis, esophageal cancer, colorectal cancer, or inflammatory bowel disease. Moreover, several authors showed that salivary miRNAs may confidently be used as biomarkers of gastric cancer, but the use of salivary miRNA candidates in gastric inflammation and pre-malignant lesions, essential stages of Correa’s cascade, is still put into question. On the other hand, besides miRNAs, other salivary omics have shown biomarker potential in gastro-intestinal conditions. The limited available data suggest that salivary miRNAs may represent reliable biomarker candidates for gastrointestinal conditions. However, their diagnostic potential requires validation through future research, performed on larger cohorts.

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Section: Introductionmentioning

confidence: 95%

Role of salivary miRNAs in the diagnosis of gastrointestinal disorders: a mini-review of available evidence

Săsăran

Bănescu

2023

Front. Genet.

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“…miRNA miRNAs are a class of small non-coding RNAs that play a regulatory role at the posttranscriptional level by recognizing binding sites in the untranslated regions of target genes, leading to mRNA degradation or protein translation inhibition [54,55]. Recently, miRNAs have played important roles in mammalian oocyte maturation, follicular development, and early embryonic development [56][57][58].…”

Section: Histone Modificationmentioning

confidence: 99%

Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro

Mo,

Ma,

Xiong

et al. 2023

Genes

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The yak (Bos grunniens) is a unique breed living on the Qinghai–Tibet Plateau and its surrounding areas, providing locals with a variety of vital means of living and production. However, the yak has poor sexual maturity and low fertility. High-quality mature oocytes are the basis of animal breeding technology. Recently, in vitro culturing of oocytes and embryo engineering technology have been applied to yak breeding. However, compared to those observed in vivo, the maturation rate and developmental capacity of in vitro oocytes are still low, which severely limits the application of in vitro fertilization and embryo production in yaks. This review summarizes the endogenous and exogenous factors affecting the in vitro maturation (IVM) and developmental ability of yak oocytes reported in recent years and provides a theoretical basis for obtaining high-quality oocytes for in vitro fertilization and embryo production in yaks.

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miR-155-5p improves oocyte maturation in porcine cumulus cells through connexin 43-mediated regulation of MPF activity

Cheng,

Chen,

Han

et al. 2024

Theriogenology

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MicroRNA-101 regulates oocyte maturation in vitro via targeting HAS2 in porcine cumulus cells

Cited by 5 publications

References 35 publications

Role of salivary miRNAs in the diagnosis of gastrointestinal disorders: a mini-review of available evidence

Role of salivary miRNAs in the diagnosis of gastrointestinal disorders: a mini-review of available evidence

Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro

miR-155-5p improves oocyte maturation in porcine cumulus cells through connexin 43-mediated regulation of MPF activity

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