2015
DOI: 10.1152/ajpheart.00290.2015
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MicroRNA-141 regulates the expression level of ICAM-1 on endothelium to decrease myocardial ischemia-reperfusion injury

Abstract: A growing number of studies have suggested microRNAs (miRNAs) are involved in the modulation of myocardial ischemia-reperfusion (MI/R) injury; however, the role of endogenous miRNAs targeting endothelial cells (ECs) and its interaction with ICAM-1 in the setting of MI/R remain poorly understood. Our microarray results showed that miR-146a, miR-146b-5p, miR-155*, miR-155, miR-497, and miR-451 were significantly upregulated, whereas, miR-141 and miR-564 were significantly downregulated in the ECs challenged with… Show more

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Cited by 61 publications
(48 citation statements)
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“…The detailed process mainly referred to previous documents. 25 To measure the change, we added QUE and QUE/P in HUVECs, and treated by tumor necrosis factor-α (TNF-α), added carboxyfluorescein diacetate succinimidyl ester-labeled acute promyelocytic leukemia (HL-60) leukocytes, washed the mixtures, and checked leukocyte binding to the ECs. Neutrophil adhesion in vivo was observed by immunofluorescence microscopy method.…”
Section: Que/p Suppresses Neutrophil Adhesion In Vivomentioning
confidence: 99%
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“…The detailed process mainly referred to previous documents. 25 To measure the change, we added QUE and QUE/P in HUVECs, and treated by tumor necrosis factor-α (TNF-α), added carboxyfluorescein diacetate succinimidyl ester-labeled acute promyelocytic leukemia (HL-60) leukocytes, washed the mixtures, and checked leukocyte binding to the ECs. Neutrophil adhesion in vivo was observed by immunofluorescence microscopy method.…”
Section: Que/p Suppresses Neutrophil Adhesion In Vivomentioning
confidence: 99%
“…23,24 As a result, CD11b + associates with its counter receptors on ECs, mainly ICAM-1, leading to their firm adhesion and transmigration by vascular wall. 25,26 Substantial evidence indicates that expression of adhesion molecules via glomerular ECs is increased following DN. 17,27,28 Therefore, understanding discovery of ECs will improve the effective therapies, which can be applied in DN procedure.…”
mentioning
confidence: 99%
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“…38 With the discovery of circRNAs as miRNA sponges, it is tempting to speculate that mcircRasGEF1B could sequester miRNAs targeting ICAM-1. The expression of ICAM-1 has been shown to be regulated by several miRNAs, including miR-223, 39 miR-141, 40 and miR-296-3p. 41 However, sequence analysis of mcircRasGEF1B does not reveal any enrichment of multiple ( 3) binding sites for any known miRNAs within mcircRasGEF1B, and it harbors no binding sites for miR-223, miR-141 and miR-296-3p (data not shown).…”
Section: Discussionmentioning
confidence: 99%
“…The TSG dose was selected based on previous studies [16,27,28] . Two weeks after the treatment, MI/R surgery was performed as previously described [29] . Briefly, C57Bl/6 mice were anesthetized with 1% pentobarbital sodium.…”
Section: Experimental Protocolmentioning
confidence: 99%