2015
DOI: 10.1016/j.atherosclerosis.2015.10.026
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microRNA-185 modulates low density lipoprotein receptor expression as a key posttranscriptional regulator

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Cited by 65 publications
(64 citation statements)
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“…There are interesting properties of miRNA‐185 from a CVD perspective, as inhibition of this compound both decreases plasma cholesterol levels and atherosclerosis in mouse models . The field of miRNA in atherosclerosis, cholesterol haemostasis and regulation is rapidly expanding, and naturally, other miRNAs than the ones studied here could play a role .…”
Section: Discussionmentioning
confidence: 96%
“…There are interesting properties of miRNA‐185 from a CVD perspective, as inhibition of this compound both decreases plasma cholesterol levels and atherosclerosis in mouse models . The field of miRNA in atherosclerosis, cholesterol haemostasis and regulation is rapidly expanding, and naturally, other miRNAs than the ones studied here could play a role .…”
Section: Discussionmentioning
confidence: 96%
“…However, in this case induction of the primary transcript of miR-185 by SREBP-1c, results in direct targeting of SREBP2 by miR-185, thereby reducing cholesterol synthesis and uptake. Interestingly, it was also shown that miR-185 controls cholesterol uptake by directly targeting the LDLR and the LDLR-destabilizing RNA binding protein, KSRP, adding another layer of complexity to the mechanism by which miR-185 regulates cholesterol homeostasis 83 . Nonetheless, the therapeutic potential of miR-185 is promising as Jiang et al showed that inhibiting miR-185 expression significantly decreased plasma LDL and reduced atherosclerosis progression ApoE −/− mice 83 .…”
Section: Mirna Regulation Of Ldl Metabolismmentioning
confidence: 99%
“…In the absence of an infection or IFN treatment, data from hepatocytes show that miR-185 expression is downregulated when cholesterol is depleted in vitro and that expression of this miRNA is directly regulated by SREBP1c via a single sterol response element in its promoter (135). Multiple studies have further shown that this miRNA can regulate SR-BI, SREBP1c, SREBP2, HMGCR, and LDLR transcript abundance (126, 136, 137). Notably, in 2015, Li et al showed that HCV can upregulate SREBP2 via a core protein-mediated suppression of miR-185 (138) while Singaravelu et al demonstrated that miR-185 expression in hepatocytes is upregulated by 25-HC and restricts HCV replication via a repression of cellular lipid uptake and biosynthesis (111).…”
Section: Mir-185 Is Regulated By 25-hc and Inhibits Virus Replicationmentioning
confidence: 99%