MicroRNA-187 induces diffuse large B-cell lymphoma cell apoptosis via targeting BCL6

Abstract

Abstract. MicroRNAs (miRs) are endogenous non-coding RNAs that serve key functions in a wide range of biological processes, including cell growth, development, apoptosis and carcinogenesis. However, the association between miR-187 and B-cell lymphoma 6 (BCL6) has yet to be fully investigated in lymphoma cell apoptosis. The present study hypothesized that a post-translational mechanism may exist for BCL6 expression, which is regulated by miR-187 in lymphoma cells. The present study demonstrated that the expression of miR-187 in diffuse large B-cell lymphoma (DLBCL) cells was significantly decreased, and its expression was negatively correlated with BCL6 expression. It was also observed that miR-187 directly binds to the 3'-untranslated region of BCL6 mRNA and subsequently suppresses the expression of BCL6. Additionally, the induced expression of miR-187 significantly promoted DLBCL cell apoptosis in vitro. The drug sensitivity of human DLBCL SUDHL2 cells was increased following induction of miR-187 overexpression via an miR-187 mimic. In conclusion, the results of the present study suggest that the modulation of miR-187 expression in DLBCL cells may improve the sensitivity of chemotherapy through BCL6 targeting.

Downregulation of miR-10b promotes osteoblast differentiation through targeting Bcl6

“…miR-187 suppresses lung cancer development by targeting Bcl6 (51). Consistently, the targeting of Bcl6 by miR-187 also functions in regulating diffuse large B-cell lymphoma cell apoptosis (52). Here, our study for the first time reported that miR-10b is a novel miRNA that targets and modulates Bcl6 expression in osteoblasts.…”

MicroRNA profiling in the dentate gyrus in epileptic rats

“…miR-187 has been reported to be related to certain types of cancer and other diseases. [ 31 , 32 ] For instance, Zhang et al showed that decreased miR-187 expression could induce retinal ganglion cell apoptosis through upregulating SMAD Family Member 7 (SMAD7) in glaucoma. [ 32 ] In accordance with this study, we determined that the target genes of miR-187-3p could be enriched in the positive regulation of cell proliferation, suggesting that miR-187-3p may play a critical role in regulating cell proliferation and apoptosis associated with the progression of epilepsy.…”

Non‐coding and coding genomic variants distinguish prostate cancer, castration‐resistant prostate cancer, familial prostate cancer, and metastatic castration‐resistant prostate cancer from each other

“…UTR variants on BCL6 (apoptosis-regulating transcription factor) in this study, we suggest that the interaction of targeting microRNAs, including microRNA-10a, 59 microRNA-187, 60 and microRNA-187-3p 61 should be further investigated in prostate cancer. As transcription factors and microRNAs are master regulators of cell systems biology, transcription factor-microRNA interactions are clearly of high impor-tance in cancer studies.…”