MicroRNA-204 regulates osteogenic induction in dental follicle cells

Ito, Katsuhiko; Tomoki, Risa; Ogura, Naomi; Takahashi, Kosuke; Eda, Takashi; Yamazaki, Fumie; Kato, Yoshihiro; Goss, Alastair N.; Kondoh, Toshirou

doi:10.1016/j.jds.2019.11.004

Cited by 7 publications

(2 citation statements)

References 22 publications

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“…While little is known about molecular targets in DFCs, miR-101 is involved in the expression of DLX3 and the activity of ALP [ 75 ]. In contrast to miR-101, miR-204 is down-regulated during osteogenic differentiation of DFCs and binds to the three prime untranslated regions (3′-UTR) of ALP and RUNX2 messenger RNAs [ 78 ]. Thus, miR-204 inhibits both expression of RUNX2 and the activity of ALP and is, therefore, an inhibitor of osteogenic differentiation in DFCs.…”

Section: Molecular Mechanisms Of the Osteogenic Differentiation Of Dfcsmentioning

confidence: 99%

Mechanisms during Osteogenic Differentiation in Human Dental Follicle Cells

Morsczeck

2022

IJMS

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Human dental follicle cells (DFCs) as periodontal progenitor cells are used for studies and research in regenerative medicine and not only in dentistry. Even if innovative regenerative therapies in medicine are often considered the main research area for dental stem cells, these cells are also very useful in basic research and here, for example, for the elucidation of molecular processes in the differentiation into mineralizing cells. This article summarizes the molecular mechanisms driving osteogenic differentiation of DFCs. The positive feedback loop of bone morphogenetic protein (BMP) 2 and homeobox protein DLX3 and a signaling pathway associated with protein kinase B (AKT) and protein kinase C (PKC) are presented and further insights related to other signaling pathways such as the WNT signaling pathway are explained. Subsequently, some works are presented that have investigated epigenetic modifications and non-coding ncRNAs and their connection with the osteogenic differentiation of DFCs. In addition, studies are presented that have shown the influence of extracellular matrix molecules or fundamental biological processes such as cellular senescence on osteogenic differentiation. The putative role of factors associated with inflammatory processes, such as interleukin 8, in osteogenic differentiation is also briefly discussed. This article summarizes the most important insights into the mechanisms of osteogenic differentiation in DFCs and is intended to be a small help in the direction of new research projects in this area.

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Section: Molecular Mechanisms Of the Osteogenic Differentiation Of Dfcsmentioning

confidence: 99%

Mechanisms during Osteogenic Differentiation in Human Dental Follicle Cells

Morsczeck

2022

IJMS

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“…MiR-218 has been confirmed to target Runx2 and play important inhibitory roles in the osteogenic differentiation of PDLSCs, DPSCs and GSCs ( Gay et al, 2014 ). MiR-204 negatively regulates the osteogenic differentiation of human DFPCs (hDPCs) by targeting Runx2 and ALP ( Ito et al, 2020 ).…”

Section: Regulatory Mechanisms Of Ncrnas In the Differentiation Of Dmscsmentioning

confidence: 99%

Progress in the Study of Non-Coding RNAs in Multidifferentiation Potential of Dental-Derived Mesenchymal Stem Cells

Zeng

2022

Front. Genet.

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For decades, the desire for tissue regeneration has never been quenched. Dental-derived mesenchymal stem cells (DMSCs), with the potential of self-renewal and multi-directional differentiation, have attracted much attention in this topic. Growing evidence suggests that non-coding RNAs (ncRNAs) can activate various regulatory processes. Even with a slight decrease or increase in expression, ncRNAs can weaken or even subvert cellular fate. Therefore, a systematic interpretation of ncRNAs that guide the differentiation of DMSCs into cells of other tissue types is urgently needed. In this review, we introduce the roles of ncRNAs in the differentiation of DMSCs, such as osteogenic differentiation, odontogenic differentiation, neurogenic differentiation, angiogenic differentiation and myogenic differentiation. Additionally, we illustrate the regulatory mechanisms of ncRNAs in the differentiation of DMSCs, such as epigenetic regulation, transcriptional regulation, mRNA modulation, miRNA sponges and signalling. Finally, we summarize the types and mechanisms of ncRNAs in the differentiation of DMSCs, such as let-7 family, miR-17∼92 family, miR-21, lncRNA H19, lncRNA ANCR, lncRNA MEG3, circRNA CDR1as and CircRNA SIPA1L1. If revealing the intricate relationship between ncRNAs and pluripotency of DMSCs 1 day, the application of DMSCs in regenerative medicine and tissue engineering will be improved. Our work could be an important stepping stone towards this future.

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