MicroRNA‑218 aggravates H₂O₂‑induced damage in PC12 cells via spred2‑mediated autophagy

MiR-218 promotes oxidative stress and inflammatory response by inhibiting SPRED2-mediated autophagy in HG-induced HK-2 cells

“…In a recent study, miR-218 was found to regulate SPRED2 expression in PC12 cells. 51 Therefore, we hypothesized that miR-218 might promote the development of DN by inhibiting SPRED2-mediated autophagy. Our results showed that miR-218 negatively regulated SPRED2 expression in HK-2 cells.…”