MicroRNA-9 controls dendritic development by targeting REST

Giusti, Sebastián; Vogl, Annette M.; Brockmann, Marisa M; Vercelli, Claudia Alejandra; Rein, Martin; Trümbach, Dietrich; Wurst, Wolfgang; Cazalla, Demián; Stein, Valentin; Deussing, Jan M.; Refojo, Damián

doi:10.7554/elife.02755

Cited by 96 publications

(70 citation statements)

References 99 publications

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“…Following on from this, miR-134 overexpression was shown to reduce cortical pyramidal neuron dendritogenesis in the mouse brain in vivo (Christensen et al, 2010). In addition, miR-9 was shown to be necessary for proper dendrite development in the mouse brain (Giusti et al, 2014) and in Drosophila melanogaster sensory neurons , suggesting that the function of miR-9 in dendrite development is conserved. The importance of these roles for miRNAs in controlling neuronal morphogenesis is highlighted by recent studies of disease states.…”

Section: Neuronal Polarization Axon Pathfinding and Dendritogenesismentioning

confidence: 86%

MicroRNAs in neural development: from master regulators to fine-tuners

2017

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The proper formation and function of neuronal networks is required for cognition and behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to neurodevelopmental disorders such as autism, schizophrenia or intellectual disability. It is wellestablished that transcriptional programs play major roles in neural circuit development. However, in recent years, post-transcriptional control of gene expression has emerged as an additional, and probably equally important, regulatory layer. In particular, it has been shown that microRNAs (miRNAs), an abundant class of small regulatory RNAs, can regulate neuronal circuit development, maturation and function by controlling, for example, local mRNA translation. It is also becoming clear that miRNAs are frequently dysregulated in neurodevelopmental disorders, suggesting a role for miRNAs in the etiology and/or maintenance of neurological disease states. Here, we provide an overview of the most prominent regulatory miRNAs that control neural development, highlighting how they act as 'master regulators' or 'fine-tuners' of gene expression, depending on context, to influence processes such as cell fate determination, cell migration, neuronal polarization and synapse formation.

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Section: Neuronal Polarization Axon Pathfinding and Dendritogenesismentioning

confidence: 86%

MicroRNAs in neural development: from master regulators to fine-tuners

2017

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“…These contain multiple binding sites for the miRNA of interest, thereby specifically inhibiting a given miRNA and de-repressing its RNA targets [10][11][12][13] . miRNA sponges are thus potent miRNA inhibitors.…”

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confidence: 99%

A non-coding function of TYRP1 mRNA promotes melanoma growth

et al. 2017

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“…MicroRNAs have been shown to play a fundamental role in migration and integration; processes that are critical for the architecture of the brain. 45 miRNAs especially miR-9, 46 miR-132 47 and miR-134 48 have been shown to play a regulatory role in dendritic development and maturation in experimental models.…”

Section: Micrornas In Neurodegenerative Diseasesmentioning

confidence: 99%

MicroRNAs in health and disease

2017

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MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs about 21-25 nucleotides in length and account for 1%-5% of the genome. Ever since its discovery in 1993, these molecules have attracted researchers due to their crucial role in regulating gene expression. Dysregulation in miRNA expression profile could serve as molecular signatures for identifying diseases. These have found applications in a number of diseases including cancer, wherein they may be useful for as biomarkers in cancer diagnosis as well as serve as therapeutic targets. This review provides an update on the evolution of miRNAs in the field of medicine and its future therapeutic applications.

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MicroRNA-9 controls dendritic development by targeting REST

Cited by 96 publications

References 99 publications

MicroRNAs in neural development: from master regulators to fine-tuners

MicroRNAs in neural development: from master regulators to fine-tuners

A non-coding function of TYRP1 mRNA promotes melanoma growth

MicroRNAs in health and disease

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