MicroRNA and target gene expression based clustering of oral cancer, precancer and normal tissues

Roy, Roshni; Singh, Richa; Chattopadhyay, Esita; Ray, Anindita; Sarkar, Navonil De; Aich, Ritesh; Paul, Ranjan Rashmi; Pal, Mousumi; Roy, Bidyut

doi:10.1016/j.gene.2016.08.011

Cited by 31 publications

(28 citation statements)

References 39 publications

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“…The expression of vascular endothelial growth factor A, which is the target gene of miR-150-5p [ 36 ], was significantly associated with the tumor stage [ 37 ]. In OSCC, increased expression of miR-423-5p was demonstrated in plasma and tissues; however, another study reported a down-regulation in miR-423 in OSCC tissues [ 38 ]. Nonetheless, these findings suggest that the identified miRNA in this study acts as an oncomiR during tumor development.…”

Section: Discussionmentioning

confidence: 99%

A Three–MicroRNA Signature as a Potential Biomarker for the Early Detection of Oral Cancer

Chang

Weng

Yang

et al. 2018

IJMS

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Oral squamous cell carcinoma (OSCC) is often diagnosed at a late stage and may be malignantly transformed from oral leukoplakia (OL). This study aimed to identify potential plasma microRNAs (miRNAs) for the early detection of oral cancer. Plasma from normal, OL, and OSCC patients were evaluated. Small RNA sequencing was used to screen the differently expressed miRNAs among the groups. Next, these miRNAs were validated with individual samples by quantitative real-time polymerase chain reaction (qRT-PCR) assays in the training phase (n = 72) and validation phase (n = 178). The possible physiological roles of the identified miRNAs were further investigated using bioinformatics analysis. Three miRNAs (miR-222-3p, miR-150-5p, and miR-423-5p) were identified as differentially expressed among groups; miR-222-3p and miR-423-5p negatively correlated with T stage, lymph node metastasis status, and clinical stage. A high diagnostic accuracy (Area under curve = 0.88) was demonstrated for discriminating OL from OSCC. Bioinformatics analysis reveals that miR-423-5p and miR-222-3p are significantly over-expressed in oral cancer tissues and involved in various cancer pathways. The three-plasma miRNA panel may be useful to monitor malignant progression from OL to OSCC and as potential biomarkers for early detection of oral cancer.

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Section: Discussionmentioning

confidence: 99%

A Three–MicroRNA Signature as a Potential Biomarker for the Early Detection of Oral Cancer

Chang

Weng

Yang

et al. 2018

IJMS

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“…, Roy et al. ), reactive gingival lesions (Elanagai et al. ), and other oral mucosal diseases (Danielsson et al.…”

Section: Discussionmentioning

confidence: 99%

Human gingiva transcriptome during wound healing

Wang

Tatakis

2017

J Clinic Periodontology

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“…The abnormal expression of miR-423 has been discovered in multiple cancers, but the potential role of miR-423 in cancer is complicated and varies in different cancer types. Different expression patterns of miR-423 have been found; for example, miR-423 is under-expressed in oral cancer 42 but over-expressed in head and neck cancer 43 . MiR-423 acts as a tumor suppressor in some tumors 42 , but as an oncogene in the other ones 44 .…”

Section: Discussionmentioning

confidence: 99%

miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk

Xiong

et al. 2018

J. Cancer

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Wilms tumor (WT) is the most prevalent urologic malignancy in childhood. Nonetheless, the genetic factors underlying WT remain largely unknown. The miR-423 rs6505162 C>A polymorphism is associated with the susceptibility to numerous cancers; however, no investigations have been conducted on its association with WT. To evaluate the correlation between the miR-423 rs6505162 C>A polymorphism and WT risk in Chinese children, we genotyped this polymorphism using the Taqman method in 145 cases and 531 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the association. The results showed that the rs6505162 CA genotype was associated with decreased susceptibility to WT (CA versus CC: adjusted OR=0.65, 95% CI=0.42-0.99, P=0.047). In the stratified analysis, we found that CA/AA genotypes conferred a significantly decreased overall risk of WT in children younger than 18 months (adjusted OR=0.30, 95% CI=0.14-0.63, P=0.002) and those with clinical stage I+II WT (adjusted OR=0.42, 95% CI=0.20-0.85, P=0.017) when compared with CC genotype. In summary, the miR-423 rs6505162 C>A polymorphism may negatively modify WT susceptibility in Chinese children. Our findings should be validated in larger studies involving other ethnicities.

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MicroRNA and target gene expression based clustering of oral cancer, precancer and normal tissues

Cited by 31 publications

References 39 publications

A Three–MicroRNA Signature as a Potential Biomarker for the Early Detection of Oral Cancer

A Three–MicroRNA Signature as a Potential Biomarker for the Early Detection of Oral Cancer

Human gingiva transcriptome during wound healing

miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk

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