2014
DOI: 10.2147/pgpm.s61693
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MicroRNA binding site polymorphisms as biomarkers in cancer management and research

Abstract: MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression. They have been implicated in a broad range of biological processes, and miRNA-related genetic alterations probably underlie several human diseases. Single nucleotide polymorphisms of transcripts may modulate the posttranscriptional regulation of gene expression by miRNAs and explain interindividual variability in cancer risk and in chemotherapy response. On the basis of recent association studies published in the literature, the present… Show more

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Cited by 21 publications
(10 citation statements)
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References 148 publications
(207 reference statements)
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“…In recent years, there has been a growing interest in the role of post-transcriptional regulation of gene expression modulated by microRNAs (miRNAs). In concomitance, the importance of the SNPs located within miRNA-binding target sites (miRSNPs) on cancer risk has been highlighted [ 18 , 19 ]. Regulation and coordination between genes involved in the DNA repair pathways are fundamental for maintaining genome stability, and post-transcriptional gene regulation by miRNAs is one of the critical players in these processes [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…In recent years, there has been a growing interest in the role of post-transcriptional regulation of gene expression modulated by microRNAs (miRNAs). In concomitance, the importance of the SNPs located within miRNA-binding target sites (miRSNPs) on cancer risk has been highlighted [ 18 , 19 ]. Regulation and coordination between genes involved in the DNA repair pathways are fundamental for maintaining genome stability, and post-transcriptional gene regulation by miRNAs is one of the critical players in these processes [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…Thus, subtle effects displayed by SNPs in DNA repair signaling genes may account for some of these variations. In this sense, specific polymorphisms in regulatory regions such as miRNA target sites may also modulate survival and response to therapy in cancer patients [ 18 , 21 ].…”
Section: Introductionmentioning
confidence: 99%
“…In terms of trying to understand the function of mutations or polymorphisms in miRNA genes and targets, the field of cancer biology has been in the forefront [20]. Similar work in the field of skeletal biology is in its infancy.…”
Section: Approach For This Reviewmentioning
confidence: 99%
“…4 This KRAS-variant allele is also highly prevalent in women with ovarian cancer diagnosed in the post-menopausal period and appears to mediate alternative and seemingly paradoxical cellular responses to exogenous factors such as chemotherapy drugs. 5 This combination of clinical observations led McVeigh and colleagues to investigate how estrogen might impact breast cancer risk and tumor biology for individuals with the KRAS-variant allele. 6 In their study, 1712…”
mentioning
confidence: 99%
“…7 With this precedent in mind and with further research, miRNA binding site polymorphisms, which appear to be promising markers of cancer risk and treatment efficacy, may prove to have considerable utility in the clinical setting. 5 …”
mentioning
confidence: 99%