MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis

He, Jieyu; Zhao, Jun; Zhu, Wenbo; Qi, Daxun; Wang, Lina; Sun, Jinfang; Wang, Bei; Ma, Xu; Dai, Qi; Yu, Xiaofang

doi:10.7717/peerj.2706

Cited by 22 publications

(17 citation statements)

References 47 publications

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“…Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of primary miRNA (pre-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) by Exportin 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER, however, DROSHA and DICER are essential for the miRNA maturation during the canonical miRNA pathway, but XPO5 can be complemented by alternative mechanisms [6]. In some pathological conditions, there has a dysregulation of this miRNA processing machinery components, such as the expression levels of Drosha and Dicer are down-regulated in ovarian cancer and neuroblastomas, while Exportin-5 is also down-regulated in bladder cancer [7]. When these matured miRNAs are processed and expressed, they bind to partially complementary sites in target mRNAs, leading to mRNA degradation or protein translation interference causing translational repression, mRNA destabilization, and/or mRNA cleavage for post-transcriptional regulation of protein synthesis [8,9].…”

Section: Mirnas: Treatment and Main Problemsmentioning

confidence: 99%

Cross-talk of MicroRNA and hydrogen sulfide: A novel therapeutic approach for bone diseases

Zhai

Tyagi

2017

Biomedicine & Pharmacotherapy

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Bone homeostasis requires a balance between the bone formation of osteoblasts and bone resorption of osteoclasts to maintain ideal bone mass and bone quality. An imbalance in bone remodeling processes results in bone metabolic disorders such as osteoporosis. Hydrogen sulfide (H2S), a gasotransmitter, has attracted the focus of many researchers due to its multiple physiological functions. It has been implicated in anti-inflammatory, vasodilatory, angiogenic, cytoprotective, anti-oxidative and anti-apoptotic mechanisms. H2S has also been shown to exert osteoprotective activity through its anti-inflammatory and anti-oxidative effects. However, the underlying molecular mechanisms by which H2S mitigates bone diseases are not completely understood. Experimental evidence suggests that H2S may regulate signaling pathways by directly influencing a gene in the cascade or interacting with some other gasotransmitter (carbon monoxide or nitric oxide) or both. MicroRNAs (miRNAs) are short non-coding RNAs which regulate gene expression by targeting, binding and suppressing mRNAs; thus controlling cell fate. Certainly, bone remodeling is also regulated by miRNAs expression and has been reported in many studies. MicroRNAs also regulate H2S biosynthesis. The inter-regulation of microRNAs and H2S opens a new possibility for exploring the H2S-microRNA crosstalk in bone diseases. However, the relationship between miRNAs, bone development, and H2S is still not well explained. This review focuses on miRNAs and their roles in regulating bone remodeling and possible mechanisms behind H2S mediated bone loss inhibition, H2S-miRNAs crosstalk in relation to the pathophysiology of bone remodeling, and future perspectives for miRNA-H2S as a therapeutic agent for bone diseases.

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Section: Mirnas: Treatment and Main Problemsmentioning

confidence: 99%

Cross-talk of MicroRNA and hydrogen sulfide: A novel therapeutic approach for bone diseases

Zhai

Tyagi

2017

Biomedicine & Pharmacotherapy

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“…microRNA (miR or miRNA) is an endogenous single-stranded small non-coding RNA, 18-25 nucleotides in length. miRNAs can bind to the 3'-untranslated region (UTR) of their target gene mRNAs to affect the stability of the mRNA, resulting in complete degradation or protein translation inhibition and negatively regulating gene expression at the post-transcriptional level (16). Numerous studies have demonstrated that the abnormal expression of miRNAs serves tumor-promoting or suppressing roles in the pathogenesis of malignant tumors and can affect tumor invasion and metastasis by regulating the expression of key genes (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

miR‑200b regulates breast cancer cell proliferation and invasion by targeting radixin

Yuan¹,

Chu

Lu³

et al. 2020

Exp Ther Med

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Radixin is an important member of the Ezrin-Radixin-Moesin protein family that is involved in cell invasion, metastasis and movement. microRNA (miR)-200b is a well-studied microRNA associated with the development of multiple tumors. Previous bioinformatics analysis has demonstrated that miR-200b has a complementary binding site in the 3'-untranslated region of radixin mRNA. The present study aimed to investigate the role of miR-200b in regulating radixin expression, cell proliferation and invasion in breast cancer. Breast cancer tissues at different Tumor-Node-Metastasis (TNM) stages were collected; breast tissues from patients with hyperplasia were used as a control. miR-200b and radixin mRNA expression levels were tested by reverse transcription-quantitative PCR. Radixin protein expression was detected by western blotting. The highly metastatic MDA-MB-231 cells were divided into four groups and transfected with a miR-negative control (NC), miR-200b mimic, small interfering (si)RNA-NC or siRNA targeting radixin. Cell invasion was evaluated by Transwell assay and cell proliferation was assessed by 5-ethynyl-2'-deoxyuridine staining. Compared with the control group, radixin mRNA expression was significantly higher in breast cancer tissues and increased with TNM stage. miR-200b expression levels exhibited the opposite trend. Radixin mRNA expression in breast cancer cells was notably higher, whereas miR-200b expression was lower compared with that in normal breast epithelial MCF-10A cells. The expression of radixin was higher, whereas miR-200b was lower in MDA-MB-231 cells compared with that in MCF-7 cells. miR-200b mimic or siRNA-radixin transfection downregulated the expression of radixin in MDA-MB-231 cells and attenuated the invasive and proliferative abilities of these cells. miR-200b-knockdown and radixin overexpression were associated with enhanced cell invasion in breast cancer. In conclusion, miR-200b regulates breast cancer cell proliferation and invasion by targeting radixin expression.

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“…In the process of cell proliferation, transformation and tumorigenesis, miRNAs have been found to play essential roles . Specifically, more and more evidence has identified that abnormal miRNA expression is required for the initiation and procession of tumours . For melanoma, a battery of miRNAs has been found to be dysregulated .…”

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confidence: 99%

Gambogic Acid Inhibits Melanoma through Regulation of miR‐199a‐3p/ZEB1 Signalling

Liang

Zhang

Qin

et al. 2018

Basic Clin Pharma Tox

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Malignant melanoma is an aggressive form of cancer which is highly resistant to chemotherapy. We have previously found that gambogic acid (GA), a kind of polyprenylated xanthone, exhibits an antitumour role in melanoma. The study was designed to investigate novel mechanisms of the antitumour effect of GA in melanoma cells and implanted nude mice. Gambogic acid significantly decreased cell viability, increased apoptosis and reduced migration and invasion in A375 cells. In addition, cisplatin-induced cytotoxicity in both A375 and A375/CDDP cells was increased by GA. The expression of miR-199a-3p was increased by GA in A375 cells and implanted tumours, and inhibition of miR-199a-3p significantly prevented GA-induced effect on cell viability, apoptosis, migration, invasion and cisplatin sensitivity in A375 cells. miR-199a-3p mimics reduced tumour weight and volume in vivo and decreased cell viability, increased apoptosis and reduced migration and invasion in vitro. miR-199a-3p expression was decreased in melanoma tissues and cells, as compared with their controls. miR-199a-3p possessed a potential binding site in the 3'-UTR of zinc finger E-box binding homeobox (ZEB1). ZEB1 expression was increased in melanoma tissues and cells, as compared with their controls. ZEB1 and miR-199a-3p expression was negatively correlated in melanoma tissues. The expression of ZEB1 was decreased by GA in A375 cells and implanted tumours, and up-regulation of ZEB1 significantly prevented GA-induced effect on cell viability, apoptosis, migration, invasion and cisplatin sensitivity. Down-regulation of ZEB1 reduced tumour weight and volume in vivo and decreased cell viability, increased apoptosis and reduced migration and invasion in vitro. We identified the important roles of miR-199a-3p and ZEB1 in melanoma and elucidated the tumour suppressor function of miR-199a-3p through inhibition of ZEB1. The results highlight the importance of miR-199a-3p-ZEB1 signalling in antitumour effect of GA in malignant melanoma and provide novel targets for the chemotherapy of melanoma.

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MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis

Cited by 22 publications

References 47 publications

Cross-talk of MicroRNA and hydrogen sulfide: A novel therapeutic approach for bone diseases

Cross-talk of MicroRNA and hydrogen sulfide: A novel therapeutic approach for bone diseases

miR‑200b regulates breast cancer cell proliferation and invasion by targeting radixin

Gambogic Acid Inhibits Melanoma through Regulation of miR‐199a‐3p/ZEB1 Signalling

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